Medication rules of diabetic retinopathy based on the analysis of modern traditional Chinese medicine medical case literature
YAO Chanyuan
QI Yue
Abstract：Objective To explore the medication rules of traditional Chinese medicine(TCM)for diabetic retinopa-thy(DR)based on modern literature of TCM medical records and to provide an evidence-based foundation for clinical diag-nosis and treatment.Methods We retrieved TCM medical records on DR published between January 1991 and Decem-ber 2023 from CNKI,Wanfang,VIP,and other databases.After screening based on inclusion and exclusion criteria,we established a prescription database.We used Excel for frequency analysis,as well as analysis of the nature,flavor,merid-ian tropism and efficacy,IBM SPSS Modeler for association rule analysis of high-frequency drugs,and SPSS Statistics for hierarchical cluster analysis.Results A total of 167 valid literatures were included,with 203 prescriptions extracted,involving 260 kinds of Chinese medicines and a cumulative frequency of 2,719 times.There were 30 high-frequency Chi-nese medicines with a frequency≥26,and the top five were Huangqi(Astragalus membranaceus),Dihuang(Rehmannia glutinosa),Danshen(Salvia miltiorrhiza),Sanqi(Panax notoginseng),and Fuling(Poria cocos)in sequence.The effica-cies of high-frequency Chinese medicines were mainly tonic medicines(40.0%)and heat-clearing medicines(16.7%);in terms of four natures,cold,warm and neutral were predominant;in terms of five tastes,sweet,bitter and pungent were the most common;and in terms of meridian tropism,the liver meridian is the primary one.Association rule analysis showed that the top five medicinal pairs in support degree were Huangqi-Dihuang,Xuanshen(Scrophularia ningpoensis)-Dihuang,Danshen-Huangqi,Baimaogen(Imperata cylindrica)-Dihuang,and Zexie(Alisma orientale)-Fuling.Cluster-ing analysis revealed five categories of core medicinal combinations:Category Ⅰ(13 kinds):Fuling,Zexie,Mudanpi(Moutan cortex),Mohanlian(Eclipta prostrata),Puhuang(Typha angustifolia),Shanyao(Dioscorea opposita),Shan-zhuyu(Cornus officinalis),Shudihuang(Rehmannia glutinosa libosch),Maidong(Ophiopogon japonicus),Dangshen(Codonopsis pilosula),Baimaogen,Baizhu(Atractylodes macrocephala),and Sanqi;Category Ⅱ(3 kinds):Gouqizi(Lycium barbarum),Juhua(Chrysanthemum morifolium),and Nüzhenzi(Ligustrum lucidum);Category Ⅲ(5 kinds):Dihuang,Xuanshen,Gegen(Pueraria lobata),Huangqi,and Danshen;Category Ⅳ(2 kinds):Huanglian(Coptis chi-nensis)and Cheqianzi(Plantago asiatica);Category Ⅴ(7 kinds):Baishao(Paeonia lactiflora),Chaihu(Bupleurum chi-nense),Danggui(Angelica sinensis),Chuanxiong(Ligusticum wallichii),Taoren(Prunus persica),Chishao(Paeonia veitchii),and Gancao(Glycyrrhiza uralensis).Conclusions The TCM treatment of DR mainly focuses on nourishing qi and yin,nourishing yin and clearing heat,promoting blood circulation,and removing dampness.With Huangqi-Dihuang as the core drug pair,the commonly used prescriptions include Shengmai powder,Liuwei Dihuang pills,and Qiju Dihuang pills,etc.
Keywords：diabetic retinopathymedical records of traditional Chinese medicinedata miningmedication regu-larityassociation ruleshierarchical clustering
Publication Date：2025-11-25
Online Publishing Date：2025-12-09(First online date of this platform, not the publication date of the document)
Pages：6( 61-66 )