Influence of renal function status on efficacy of intravitreal injection of ranibizumab in patients with diabetic macular oedema
GU Xiaoyuan
WANG Jun
Abstract：Objective To investigate the impact of renal function status on the efficacy of intravitreal injection of ra-nibizumab in patients with diabetic macular oedema(DME),thereby providing a basis for individualised clinical treat-ment.Methods Seventy-six patients with DME(95 eyes)were selected and divided into three groups based on estimat-ed glomerular filtration rate(eGFR):group A(normal renal function,26 patients,34 eyes),group B(mild renal impair-ment,26 patients,31 eyes),and group C(renal insufficiency,24 patients,27 eyes).All affected eyes received intravitre-al injection of 0.5 mg/0.05 mL ranibizumab using a 3+PRN injection regimen.Best-corrected visual acuity(BCVA)and central macular thickness(CMT)were measured preoperatively and at 1,2,and 3 months postoperatively.The number of eyes with DME recurrence was recorded,and recurrence rates were calculated.Results Preoperative BCVA and CMT showed no statistically significant differences between groups(all P>0.05).At 1,2,and 3 months postoperatively,BCVA and CMT decreased in all groups in comparison with the preoperative levels,with group C>group B>group A at each time point(all P<0.05).The DME recurrence rates in the groups A,B,and C were 21.2%,46.9%,and 76.7%,respective-ly;the recurrence rates of DME followed the order:group C>group B>group A(all P<0.05).Conclusions Renal func-tion status significantly influences the therapeutic efficacy of intravitreal injection of ranibizumab in DME patients.Higher eGFR correlates with greater visual acuity improvement,more complete resolution of macular oedema,and lower recur-rence risk.
Keywords：diabetic retinopathymacular oedemadiabetic macular oedemaranibizumabrenal functionesti-mated glomerular filtration ratevascular endothelial growth factor
Publication Date：2025-11-25
Online Publishing Date：2025-12-09(First online date of this platform, not the publication date of the document)
Pages：4( 57-60 )