Clinical features and prognostic risk factors of inpatients with acute pulmonary embolism in a tertiary general hospital during the COVID-19 period
ZHU Ruixia
HE Yaohong
CHEN Jin
LI Ning
LI Qian
Abstract：Objective To explore the clinical characteristics and prognostic risk factors of inpatients with acute pul-monary embolism(APE)admitted to a tertiary general hospital during the Corona Virus Disease 2019(COVID-19)peri-od.Methods A total of 114 patients with APE at Fuxing Hospital of Capital Medical University during the COVID-19 period(June 2020-June 2023)were selected.The clinical data were collected.Univariate and multivariate regression analyses were conducted to identify the risk factors for the prognosis of APE.Results Among 114 patients,the initial symptoms included 43 cases of dyspnea,17 cases of chest tightness,12 cases of hemoptysis and 10 cases of chest pain,etc.There were 29 cases with cerebrovascular disease,27 cases with pulmonary infection and 20 cases with malignant tu-mor,etc.and 24 patients died during the study period.The univariate analysis results showed that age,immobilization time>3 days,hypoxemia,whether combined with lower extremity venous thrombosis,whether combined with pulmonary hypertension,whether right ventricular enlargement,acute pulmonary embolism grade,Pudua score,D-dimer(D-D),tro-ponin T(TnT)and N-terminal pro-brain natriuretic peptide(NT-proBNP)were related to the prognosis of APE(r=-0.335,0.205,0.290,0.109,0.212,0.185,0.245,0.192,0.238,0.382,0.399,all P<0.05).Gender,smoking history,BMI,COVID-19 infection,recent surgery and the number of chronic diseases combined were not related to the prognosis of APE(r=-0.045,-0.036,-0.082,-0.045,0.0321,0.0361,all P>0.05).The multivariate analysis results showed that advanced age,immobilization time>3 days,hypoxemia,D-D and NT-proBNP were risk factors for death in APE patients during the COVID-19 period(all P<0.05).Conclusions During the COVID-19 period,the common ini-tial symptoms of APE patients admitted to this tertiary general hospital were breathing difficulties and chest tightness.The common complications were cerebrovascular diseases and pulmonary infections.The risk factors for APE death were ad-vanced age,long period of immobilization,and the presence of multiple underlying diseases.
Keywords：acute pulmonary embolismdyspneaadvanced agepulmonary hypertensionCOVID-19 pandemic
Publication Date：2025-09-25
Online Publishing Date：2025-10-22(First online date of this platform, not the publication date of the document)
Pages：5( 76-79,84 )