Value of routine laboratory test indicators in the early diagnosis of children with Kawasaki disease
DENG Bin
HE Yong
YANG Ziwei
KANG Qian
HUANG Yue
LIU Chonghai
Abstract：Objective To explore the value of routine laboratory test indicators in the early diagnosis of Kawasaki disease.Methods A total of 280 children with Kawasaki disease were enrolled in the study group,and 104 feverish children without Kawasaki disease were included in the control group.Data including gender,age,disease course,and length of hospital stay were collected from both groups,along with data of blood routine indicators,blood biochemical in-dicators,and C-reactive protein(CRP)tests.Univariate analysis and multivariate Logistic regression analysis were used to identify the influencing factors of Kawasaki disease.Receiver operating characteristic(ROC)curves were plotted to evaluate the diagnostic efficacy of blood routine indicators,CRP,and blood biochemical indicators for Kawasaki disease.Results Compared with the control group,the study group had higher levels of neutrophil count,white blood cell count,alanine aminotransferase,total bilirubin,CRP,serum creatinine,lactate dehydrogenase,total bile acid,and platelets,while lower levels of prealbumin,blood chlorine,blood potassium,and blood sodium(all P<0.05).Taking the confirma-tion of Kawasaki disease as the dependent variable and the indicators with statistically significant differences in univariate analysis as independent variables,Logistic regression analysis showed that platelets,serum creatinine,total bile acid,and blood sodium were independent influencing factors for Kawasaki disease(all P<0.05).ROC curve analysis results re-vealed that the combined detection of platelets,serum creatinine,total bile acid,and blood sodium for diagnosing Kawasa-ki disease had a sensitivity of 0.90,a specificity of 0.99,and an area under the ROC curve(AUC)of 0.985(95%CI:0.967-0.995),which was higher than that of the individual detection of each indicator.Conclusions Among common laboratory test indicators,platelets,serum creatinine,total bile acid,and blood sodium are independent influencing fac-tors for Kawasaki disease.Children with abnormal levels of these indicators should be considered for the possibility of Ka-wasaki disease.The combined detection of platelets,serum creatinine,total bile acid,and blood sodium has high efficacy in diagnosing Kawasaki disease.
Keywords：Kawasaki diseaseblood routine indicatorsblood biochemical indicatorsC-reactive proteinplate-letscreatininetotal bile acidblood sodium
Publication Date：2025-09-25
Online Publishing Date：2025-10-22(First online date of this platform, not the publication date of the document)
Pages：5( 66-69,75 )