Clinical efficacy and mechanism exploration of modified Sanpian decoction granules in the treatment of migraine
LI Lili
HE Lili
LIU Yan
Abstract：Objective To evaluate the clinical efficacy of modified Sanpian decoction granules in the treatment of mi-graine and to explore its mechanism,thereby providing additional treatment options for migraine.Methods A total of 113 patients with migraine were selected and randomly divided into the treatment group(n=57)and control group(n=56).Pa-tients in the treatment group received oral administration of modified Sanpian decoction granules,while patients in the con-trol group received oral administration of a placebo granule formulation,with both groups undergoing continuous treatment for 4 weeks.During treatment,if patients experienced severe headaches that were intolerable,they could temporarily take ibuprofen sustained-release capsules.The clinical efficacy of the two groups was compared,along with headache severity scores,headache symptom scores,and serum levels of calcitonin gene-related peptide(CGRP),serotonin(5-HT),and in-terleukin-1β(IL-1β)before and after treatment.Results The total effective rate was higher in the treatment group than in the control group(P<0.05).There was no statistically significant difference in headache severity scores between the two groups before treatment(P>0.05).After treatment,the headache severity scores and headache symptom scores in the treat-ment group were lower than those in the control group(both P<0.05).There were no statistically significant differences in serum CGRP,5-HT,or IL-1β levels between the two groups before treatment(all P>0.05);after treatment,serum CGRP,5-HT,and IL-1β levels in both groups were lower than those before treatment,and serum CGRP,5-HT,and IL-1β levels in the treatment group were lower than those in the control group(all P<0.05).Conclusion The modified Sanpian decoc-tion granules demonstrated good clinical efficacy in the treatment of migraine,and its mechanism of action may be related to multi-target effects such as improving blood flow,regulating neurotransmitters,and inhibiting inflammatory factors.
Keywords：modified Sanpian decoctionmigrainecalcitonin gene-related peptide5-hydroxytryptamineinterleukin-1β
Publication Date：2025-08-25
Online Publishing Date：2025-09-10(First online date of this platform, not the publication date of the document)
Pages：5( 67-71 )