Comparison of infection status,antibiotic usage and hospital stay among preterm infants with different serum 25-hydroxyvitamin D levels
XIE Yuyan
LI Liuqing
YAO Xuan
SHI Fenglang
LI Xinyun
Abstract：Objective To compare the infection status,antibiotic usage and hospital stay of premature infants with different serum 25-hydroxyvitamin D[25(OH)D]levels,in order to provide scientific basis for optimizing the vitamin D supplementation strategy for premature infants,reducing the incidence of infection and improving the quality of life of pre-mature infants.Methods A total of 136 premature infants admitted to the People's Hospital of Guangxi Zhuang Autono-mous Region from July 2019 to December 2023 were selected.They were divided into the low vitamin D group[25(OH)D≤50 nmol/L,65 cases]and the normal vitamin D group[25(OH)D>50 nmol/L,71 cases]based on the serum 25(OH)D levels.The infection status,use of antibiotics,and hospital stay of the two groups were compared.Results In the low vitamin D group,49 cases(75.4%)had early infections and 21 cases(32.3%)had late infections,and in the nor-mal vitamin D group,the numbers were 39 cases(54.9%)and 15 cases(21.1%),respectively;there was a significant difference in the proportion of early infection between the two groups(P<0.05).In the low vitamin D group,the early use of antibiotics was(9.0±9.8)types per day and the late use was(3.3±5.7)types per day,and in the normal vitamin D group,they were(5.6±6.8)and(2.7±6.7)types per day,respectively;significant difference was found in the early antibiotic use between the two groups(P<0.05).The length of hospital stay was(28.8±11.3)days in the low vitamin D group and(23.7±10.5)days in the normal vitamin D group,with significant difference between the two groups(P<0.05).Conclusion Compared with premature infants with normal serum 25(OH)D levels,those with low serum 25(OH)D levels are more likely to develop early infections,and they require more types of antibiotics used earlier,a longer duration of antibiotic use,and a longer hospital stay.
Keywords：25-hydroxyvitamin Dbacterial infectionantibioticslength of hospital staypremature infants
Publication Date：2025-07-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 88-91 )