Correlation analysis between metabolic score for visceral fat and albuminuria risk in elderly population

PAN Lingling; PAN Ying; WANG Zhaoxiang; XI Xiaoxia

doi:10.3969/j.issn.1002-266X.2025.07.017

Abstract：Objective To analyze the association between metabolic score for visceral fat(METS-VF)and risk of al-buminuria in the elderly population.Methods This cross-sectional study included 7,512 elderly adults aged≥60 years from the National Health and Nutrition Examination Survey(1999-2018).METS-VF was calculated based on insulin resis-tance metabolic score,waist-to-height ratio,age,and sex.Albuminuria was defined as urine albumin-to-creatinine ratio≥30 mg/g.Baseline characteristics were compared between albuminuria(n=1,593)and non-albuminuria groups(n=5,919).Subjects were also stratified by METS-VF quartiles to analyze baseline characteristic distributions and albuminuria prevalence trends.Multivariate Logistic regression,restricted cubic spline models,and subgroup analyses were performed to assess the relationship between METS-VF and albuminuria risk in elderly population.Results METS-VF levels were higher in the albuminuria group than in the non-albuminuria group,and albuminuria prevalence increased progressively with rising METS-VF quartiles.After adjusting for confounding factors,multivariate Logistic regression revealed a signifi-cant association between METS-VF and albuminuria risk with an OR(95%CI)of 1.721(1.389-2.134).Restricted cu-bic spline analysis demonstrated a J-shaped dose-response relationship with a threshold value of 6.818.Subgroup analysis indicated that the association between METS-VF and albuminuria risk was more pronounced in overweight/obese individu-als.Conclusions Elevated METS-VF is significantly associated with increased albuminuria risk in elderly population.METS-VF may serve as a valuable epidemiological indicator for quantifying the impact of visceral fat on albuminuria risk in elderly adults.