Risk factors and their predictive efficacy for depression after progressive cerebral infarction in young patients

CAI Guishu; WANG Dongmei

doi:10.3969/j.issn.1002-266X.2025.07.004

Abstract：Objective To analyze the risk factors and their predictive efficacy for depression after progressive cere-bral infarction(PIS)in young people.Methods A total of 160 young patients with PIS diagnosed by MRI were selected and divided into the depression group(37 cases)and non-depression group(123 cases)according to the results of Hamil-ton Depression Scale.Univariate and multivariate Logistic regression analyses were used to analyze the risk factors of de-pression after PIS in young people,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of risk factors for depression after PIS in young people.Results Univariate analysis showed that significant differ-ences were found in the levels of serum cortisol,NIHSS score,cerebral infarction volume and serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)]between the depression group and the non-depression group(all P<0.05).Multivariate analysis showed that serum cortisol,NIHSS score,cerebral in-farction volume and serum inflammatory factors were independent risk factors for depression after PIS in young people(all P<0.05).When the cut-off value of serum cortisol was 765.73 mmol/L,the sensitivity and specificity in predicting de-pression after PIS in young people were 0.902 and 0.875,respectively;when the cut-off value of NIHSS score was 13,the sensitivity and specificity of NIHSS score in predicting depression after PIS in young people were 0.706 and 0.918,re-spectively;when the cut-off value of cerebral infarction volume was 1.4 mm3,the sensitivity and specificity in predicting depression after youth PIS were 0.702 and 0.909,respectively;the sensitivity and specificity of serum cortisol,NIHSS score,cerebral infarction volume combined with serum inflammatory factors in predicting depression after PIS in young people were 0.955 and 0.879,respectively.Conclusions The risk factors of depression in young people after PIS in-clude serum cortisol,NIHSS score,cerebral infarction volume and serum inflammatory factors.Serum cortisol level,NI-HSS score and cerebral infarction volume can be used as predictors of depression in young people after PIS,while serum cortisol level,NIHSS score,cerebral infarction volume combined with serum inflammatory factors have higher predictive value for depression in young people after PIS.