Effects of pre-and post-pharmacotherapy serum remnant cholesterol levels on coronary lesion progression in patients with coronary atherosclerotic heart disease
CHEN Xiaoyun
XIONG Li
Abstract：Objective To investigate the effects of pre-and post-pharmacotherapy serum remnant cholesterol(RC)levels on coronary lesion progression in patients with coronary atherosclerotic heart disease(abbreviated as coronary heart disease)and to evaluate their predictive value.Methods We selected 166 patients with coronary heart disease initially confirmed by coronary angiography who were treated with medications only,and used Gensini score to assess the progres-sion of coronary lesion according to the first and the follow-up coronary angiography after an interval of no less than 6 months.We collected baseline data,pre-pharmacotherapy laboratory parameters,and post-pharmacotherapy lipid parame-ters,and calculated the per-and post-pharmacotherapy serum RC levels.Multivariate Logistic regression analysis was per-formed to identify independent risk factors for coronary lesion progression in patients with coronary heart disease undergo-ing pharmacotherapy.We drew an receiver operating characteristic(ROC)curve to evaluate the predictive efficacy of per-and post-pharmacotherapy serum RC levels for coronary lesion progression in patients with coronary heart disease.Results Among 166 patients receiving pharmacotherapy for no less than 6 months,coronary lesion progression was ob-served in 87 cases,while 79 cases showed no progression.The baseline data and laboratory parameters between the coro-nary lesion progression group and non-progression group showed no statistically significant differences(all P>0.05).The pre-pharmacotherapy serum RC levels in the coronary lesion progression group and non-progression group were 0.58(0.35,0.84)and 0.48(0.36,0.62)mmol/L,respectively,with statistically significant difference(P<0.05);the post-pharmacotherapy serum RC levels were 0.85(0.63,1.24)and 0.49(0.37,0.63),respectively,with statistically sig-nificant difference(P<0.05).Multivariate Logistic regression analysis revealed that elevated pre-pharmacotherapy serum RC(OR=1.094,95%CI:0.957-1.251,P=0.188)was not an independent risk factor for coronary lesion progression in patients with coronary heart disease,while elevated post-pharmacotherapy serum RC(OR=1.365,95%CI:1.209-1.541,P<0.05)was an independent risk factor.The AUC of pre-pharmacotherapy serum RC for diagnosing coronary lesion pro-gression was 0.626(95%CI:0.540-0.711),and the cut-off value was 0.74 mmol/L with a sensitivity of 0.368 and a specificity of 0.937.The AUC of post-pharmacotherapy serum RC for diagnosing coronary lesion progression was 0.815(95%CI:0.747-0.882),and the cut-off value was 0.67 mmol/L with a sensitivity of 0.724 and a specificity of 0.848.Conclusions The pre-and post-pharmacotherapy serum RC levels are both high in the coronary lesion progression pa-tients with coronary heart disease.Elevated post-pharmacotherapy serum RC is associated with coronary lesion progression and can be used as one of the predictive indicators for coronary lesion progression.
Keywords：remnant cholesterolcoronary atherosclerotic heart diseasecoronary lesion progressionpharmaco-therapy
Publication Date：2025-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 7-11 )