Associations between serum residual cholesterol and hs-CRP levels and heart failure in patients with AMI following PCI
LI Danni
GUO Chen
SUN Yuyu
XIA Linying
JIN Ping
LIANG Xiying
JIANG Wei
DENG Jie
Abstract：Objective To investigate the associations between serum residual cholesterol(RC)and high-sensitivity C-reactive protein(hs-CRP)levels and the incidence of heart failure in patients with acute myocardial infarction(AMI)following percutaneous coronary intervention(PCI),and to evaluate the predictive value of RC combined with hs-CRP for heart failure in AMI patients after PCI.Methods Totally 201 AMI patients who underwent PCI were enrolled and catego-rized into the heart failure group(n=75)and the non-heart failure group(n=126)based on the presence of concurrent heart failure.General information of patients was collected,including gender,age,medical history,multi-vessel coronary artery disease,TIMI grade,blood pressure,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diame-ter(LVEDD),and left ventricular end-systolic diameter(LVESD).Laboratory test results were also collected,including white blood cell count,red blood cell count,hemoglobin concentration,platelet count,hematocrit,hs-CRP,N-terminal pro-brain natriuretic peptide(NT-proBNP),fasting blood glucose,glycated hemoglobin,blood urea nitrogen,serum creat-inine,glomerular filtration rate,cystatin C,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,apolipoprotein A1,apolipoprotein B,and lipoprotein a;RC was calculated accordingly.Univariate analysis and multivariate Logistic regression analysis were conducted to explore the relationships between RC,hs-CRP,and the occurrence of heart failure in AMI patients after PCI.The receiver operating characteristic(ROC)curve was utilized to assess the predictive efficacy of RC combined with hs-CRP for heart failure in AMI patients after PCI.Results Compared with the non-heart failure group,the heart failure group was older and exhibited higher propor-tions of males,individuals with a history of diabetes,alcohol consumption,and TIMI grade 0,and elevated levels of LVEDD,LVESD,RC,hs-CRP,NT-proBNP,blood urea nitrogen,cystatin C,and lipoprotein a,while had lower levels of LVEF,red blood cell count,hemoglobin,and hematocrit(all P<0.05).Multivariate Logistic regression analysis showed that LVEF,triglycerides,hs-CRP,and RC were independent influencing factors for heart failure in AMI patients after PCI(all P<0.05).ROC curve analysis demonstrated that RC combined with hs-CRP had a certain predictive value for the occurrence of heart failure in AMI patients after PCI(area under the ROC curve=0.718,sensitivity=0.592,specificity=0.613,P<0.05).Conclusions Elevated levels of RC and hs-CRP are associated with the incidence of heart failure in AMI patients after PCI.Combined detection of these two indicators holds potential predictive value for heart failure occurrence in this population.
Keywords：acute myocardial infarctionheart failureresidual cholesterolhigh-sensitivity C-reactive proteinpercutaneous coronary intervention
Publication Date：2025-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1-6 )