Clinical efficacy of Shenfu injection in extracorporeal cardiopulmonary resuscitation for cardiac arrest patients
WU Lidong
JIANG Qin
FANG Xiaowei
MEI Shuchong
WANG Yibing
Abstract：Objective To observe the clinical efficacy of Shenfu injection(SFI)in patients with cardiac arrest(CA)undergoing extracorporeal cardiopulmonary resuscitation(ECPR).Methods Sixty CA patients were divided into the obser-vation group and control group(n=30 each)through propensity score matching analysis.Patients in both groups received con-ventional cardiopulmonary resuscitation(CPR)upon admission.ECPR was initiated when spontaneous circulation remained unestablished after 30 minutes of CPR.The observation group received intravenous infusion of 100 mL SFI+250 mL 0.5%glu-cose solution twice daily for 7 consecutive days after successful ECPR establishment.The degree of disturbance of conscious-ness was assessed using Glasgow Coma Scale(GCS)scores at admission and discharge.Survival rates on treatment day 7,15,and 30 were recorded.Clinical timelines including no-flow duration,CA-to-extracorporeal membrane oxygenation(ECMO)establishment interval,ECMO duration,hospitalization duration,and intensive care unit(ICU)stay duration were compared.Adverse events on day 7 were documented.Results At discharge,patients in both groups showed increased GCS scores compared with those at admission(all P<0.05),with lower scores in the observation group(all P<0.05).No sig-nificant differences were found in survival rates between groups on day 7,15,and 30(all P>0.05).The observation group demonstrated shorter hospitalization duration and ICU stay(both P<0.05),while no-flow duration,CA-to-ECMO interval,and ECMO duration showed no intergroup differences(all P>0.05).Adverse event rates did not differ significantly(P>0.05).Conclusion Shenfu injection may improve neurological outcomes and reduce hospitalization/ICU stay duration in ECPR-treated CA patients without increasing adverse events,but it shows no significant impact on short-term survival rates.
Keywords：cardiac arrestShenfu injectionextracorporeal cardiopulmonary resuscitation
Publication Date：2025-05-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 32-35 )