Effect of OPRM1 A118G gene polymorphism on postoperative analgesia in lung cancer patients of Zhuang nationality undergoing lobectomy
ZENG Chunlu
HUANG Ge
RUAN Haoshen
XU Wen
FU Yang
LU Bo
PANG Zixia
Abstract：Objective To investigate the effect of µ-opioid receptor(OPRM1)A118G gene polymorphism on post-operative analgesia in lung cancer patients of Zhuang nationality undergoing lobectomy.Methods Eighty-four Zhuang lung cancer patients undergoing lobectomy in Guangxi were enrolled and divided into three groups based on OPRM1 A118G genotypes:AA group(wild-type homozygotes,n=53),AG group(heterozygotes,n=22),and GG group(mutant homozygotes,n=9).All groups underwent lobectomy and received identical anesthesia induction/maintenance protocols during operation and patient-controlled intravenous analgesia postoperatively.Visual Analog Scale(VAS)scores at 2,6,12,24,and 48 h after operation were recorded,along with analgesic pump demands,sufentanil consumption,and ad-verse effects.Results No significant differences were observed in VAS scores at different time points among these three groups(all P>0.05).Compared with AA group,AG group demonstrated significantly higher analgesic pump demands and sufentanil consumption(both P<0.05).GG group required significantly more pump demands and sufentanil than both AG and AA groups(all P<0.05).There were no significant differences in the adverse events among these three groups(all P>0.05).Conclusion Zhuang lung cancer patients carrying OPRM1 A118G G allele require higher sufentanil doses for post-lobectomy analgesia.
Keywords：population of Zhuang nationalityµ-opioid receptor genegene polymorphismsufentanilpostopera-tive analgesiapulmonary lobectomy
Publication Date：2025-05-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 24-27 )