Effect of preoperative application of teriparatide on outcome of lumbar spine surgery in osteoporotic patients
WANG Ziyi
LI Jingkun
WANG Zhijin
HAN Wenzhe
ZOU Debo
Abstract：Objective To observe the clinical effect of preoperative application of teriparatide on the outcome of lum-bar spine surgery for patients with osteoporosis,and to provide reference for the clinical treatment of osteoporotic lumbar spine diseases.Methods A retrospective collection was conducted on 30 patients undergoing lumbar spine surgery for osteoporosis who received preoperative treatment with teriparatide(teriparatide group),and 30 patients undergoing lumbar spine surgery for osteoporosis who did not receive preoperative treatment with teriparatide(control group).Patients in the teriparatide group received standardized treatment with teriparatide for osteoporosis 3-6 months before surgery,and pa-tients in both groups underwent lumbar posterior fusion surgery.We compared two sets of surgical related indicators(surgi-cal time,blood loss,the number of surgical segments,and postoperative drainage volume),intervertebral fusion rate at 6 months and at the last follow-up,the occurrence of osteoporosis-related complications(screw loosening,fusion device sub-sidence,new vertebral compression fractures),bone density T values before surgery,at 3 months after surgery,and at the last follow-up,as well as Oswestry Disability Index(ODI)and Visual Analog Scale(VAS)scores for lumbar and leg pain before surgery,at 3 months after surgery,and at the last follow-up.Results There were no statistically significant differ-ences in surgical time,intraoperative blood loss,the number of surgical segments,or postoperative drainage volume be-tween the two groups(all P>0.05).The incidence of screw loosening,fusion cage settling,and new vertebral compression fractures in the teriparatide group was lower than that in the control group;the fusion rate of intervertebral bone graft at 6 months after surgery and at the last follow-up was higher than that in the control group(P<0.05).Compared with the con-trol group at the same time point,the T value of bone density in the teriparatide group was higher than that in the control group at the last follow-up(P<0.05).There was no statistically significant difference in the T value of bone density be-tween the two groups before surgery,3 months after surgery,and 3 months after surgery;compared with the same group be-fore surgery,the T value of bone density in the teriparatide group was higher at the last follow-up(P<0.05),while there was no statistically significant difference in the T value of bone density between the control group before surgery,at 3 months after surgery and at the last follow-up.There were no statistically significant differences in the preoperative ODI or VAS scores between the two groups.The ODI and VAS scores in the teriparatide group were lower than those in the control group at 3 months after surgery and at the last follow-up(all P<0.05).Conclusion Preoperative application of teripara-tide can improve the interbody fusion rate,increase bone density,and reduce the incidence of postoperative complications in patients with osteoporosis undergoing lumbar spine surgery,thereby improving the surgical treatment effect.
Keywords：teriparatideosteoporosislumbar fusionbone density
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 98-103 )