Association between sedentary behavior and risk of acute pancreatitis:a cohort study based on the UK Biobank
YANG Yuqing
DONG Xiaowu
LU Guotao
PAN Jiajia
Abstract：Objective To investigate the association between sedentary behavior and the risk of acute pancreatitis(AP)and to provide references for AP prevention.Methods A cohort of 480,716 participants from the UK Biobank was included.Exposure variable(sedentary time)and covariates(age,sex,ethnicity,education level)were collected.Sedentary time was stratified by interquartile range into four groups:<3.0,3.0-<4.5,4.5-<6.0,and≥6.0 h/d.Base-line characteristics across groups were compared.Kaplan-Meier survival curves analyzed cumulative AP incidence.Re-stricted cubic spline models fitted Cox proportional hazards models to evaluate the nonlinear relationship between sedentary time and AP risk.Incremental Cox proportional hazards model was used to analyze the impact of sedentary behavior on the risk of acute pancreatitis.Results Among 480,716 participants,2,937 developed AP(incidence:0.61%).There were significant differences in the baseline information of gender,age,ethnicity,employment status,and education level of the study participants stratified by time of sedentary behaviour(all P<0.01).Kaplan-Meier curves demonstrated higher cumulative AP incidence with prolonged sedentary time(P<0.01).Restricted cubic spline analysis revealed a nonlinear relationship between sedentary time and AP risk(P=0.016 7).Incremental Cox regression model confirmed a significant dose-response association,with risk intensifying as sedentary time increased.Conclusion Prolonged sedentary time is associated with an elevated risk of AP,exhibiting a threshold effect.
Keywords：sedentary behavioracute pancreatitisdisease riskcohort studyUK Biobank
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 88-92 )