Effect of perioperative application of bevacizumab in patients with malignant tumors on postoperative complications after infusion port implantation
LIU Mei
MU Ning
WU Shengnan
XU Yue
LYU Huan
WANG Xinyi
MA Chunhua
Abstract：Objective To observe the effect of perioperative application of bevacizumab in patients with malignant tumors on postoperative complications after infusion port implantation.Methods According to whether bevacizumab was used for anti-tumor angiogenesis therapy in perioperative period,139 patients with malignant tumor undergoing infusion port implantation were divided into the combined bevacizumab group(41 cases)and the simple treatment group(98 cas-es).All patients were followed up for more than 6 months.Postoperative complications of the two groups were recorded and compared,including early postoperative complications(≤30 d)and late postoperative complications(>30 d),and we calculated the incidence of postoperative complications.Results In the combined bevacizumab group,there was 1 case of poor wound healing,and the incidence of early complications was 2.44%.In the simple treatment group,hemor-rhage occurred in 4 cases and incision healing was poor in 1 case;the incidence of early postoperative complications was 5.10%.There were no significant differences in the incidence of early postoperative complications between the two groups(all P>0.05).In the combined bevacizumab group,there were 1 case of catheter obstruction and 1 case of infection,and the rate of late complications was 4.88%.In the simple treatment group,catheter displacement occurred in 2 cases,and the incidence of late complications was 2.04%.No significant differences were found in the incidence of late complications between the two groups(all P>0.05).Conclusion There is no significant effect of perioperative bevacizumab on postop-erative complications in patients with malignant tumors after infusion port implantation.
Keywords：perioperative periodbevacizumabinfusion port implantationpostoperative complicationsmalig-nant tumorvascular endothelial growth factor
Publication Date：2025-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 36-39 )