Application of magnetic resonance apparent diffusion coefficient in lesion localization during CT-guided lung mass aspiration biopsy
XU Long
ZHU Xiaoping
ZHANG Li
LI Xin
DUAN Haifeng
Abstract：Objective To analyze the application value of magnetic resonance apparent diffusion coefficient(ADC)in lesion localization during CT-guided percutaneous biopsy of lung masses.Methods Twenty-two patients with first puncture biopsy and 10 patients with second puncture biopsy of lung masses were selected,and chest magnetic resonance imaging(MRI)was performed before puncture,and diffusion-weighted imaging(DWI)image with b-value of 800 s/mm2 and the corresponding ADC image were obtained.For patients undergoing first puncture,low-signal areas on the DWI and high-signal areas on the ADC images were regarded as the necrotic lesion area(area A),while high-signal areas on the DWI images and low-signal areas on the ADC images were considered as lesion active area(area B).For patients undergo-ing a second puncture,the pathologically negative region identified in their first biopsy was designated as area A,while the pathologically positive region from the second biopsy was labeled as area B.The ADC values of areas A and B were com-pared.Lung tissues were obtained from both areas via CT-guided percutaneous biopsy.Pathological analysis was performed after HE staining,and the rates of pathological positivity and negativity in the two areas were evaluated.Results The ADC values in the areas A and B were 1.32(1.21,1.40)×10-3 and 0.85(0.76,0.95)×10-3 mm2/s,respectively,with statistically significant differences between these two groups(P<0.05).In the area A,27 cases(84.38%)were pathologi-cally diagnosed as benign lesions and 5 cases(15.62%)as malignant lesions.In the area B,3 cases(9.37%)were diag-nosed as benign lesions and 29 cases(90.63%)as malignant lesions.The 3 cases with benign lesions in area B were also diagnosed as benign in area A.Pathologically positive rate in the area A was 18.75%(6/32)and negative rate was 81.25%(26/32),while the pathologic positive rate in the area B was 100%(32/32),and the pathologically positive rate in the area A was lower than that in the area B(P<0.05).Conclusion Selecting the area with low ADC on pre-puncture chest MRI as the puncture target area helps to improve the pathological accuracy of CT-guided puncture biopsy in patients with lung masses.
Keywords：apparent diffusion coefficientmagnetic resonance imagingdiffusion-weighted imaginglung massaspiration biopsy
Publication Date：2025-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 22-25,45 )