Mechanism analysis of Shenfu decoction in treatment of chronic obstructive pulmonary disease
MA Haimei
ZHANG Kai
JIANG De
GUO Chunhua
YOU Li
JING Yuxia
Abstract：Objective To analyze the mechanism of action of Shenfu decoction in the treatment of chronic obstruc-tive pulmonary disease(COPD).Methods The active ingredients of Shenfu decoction and the disease targets of COPD were obtained through databases such as TCMSP and Genecards.A"drug-active component-key target-disease"network was constructed using Cytoscape software to screen the key targets of Shenfu decoction in the treatment of COPD.DAVID database was used to conduct gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis on the key targets of Shenfu decoction in the treatment of COPD.Results The main active ingredients of Shenfu decoction included kaempferol,β-sitosterol,and stigmasterol,etc.There were 108 disease targets for COPD.Nineteen key targets of Shenfu decoction in the treatment of COPD were screened out from the"drug-component-key target-disease"network,including ABCB1,MMP2,and CCND1,etc.Shenfu decoction mainly affected the inflammatory response,tissue remodeling,cell proliferation and apoptosis and other pathophysiological processes of COPD through 154 pathways such as the phosphati-dylinositol 3-kinase-protein kinase B(PI3K-AKT)signaling pathway,mitogen-activated protein kinase(MAPK)signaling pathway,and cytomegalovirus infection.Conclusion Shenfu decoction may alleviate the pulmonary inflammatory re-sponse in COPD patients by regulating the expression of ABCB1,MMP2 and CCND1 and modulating the PI3K-AKT signal-ing pathway and MAPK signaling pathway.
Keywords：Shenfu decoctionchronic obstructive pulmonary diseaseinflammatory responsenetwork pharmacology
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 16-19 )