Serum GP73 variations in patients with liver disease associated with chronic hepatitis B virus infection
WANG Huimin
TAN Bingqin
WANG Wanpeng
WU Mengxue
Abstract：Objective To investigate the changes in levels of serum golgi protein 73(GP73)in patients with liver diseases associated with chronic hepatitis B virus(HBV)infection.Methods We analyzed 279 chronic HBV-infected patients,including 52 cases of chronic hepatitis B(CHB group),125 cases of liver cirrhosis(LC group),and 102 cases of primary hepatocellular carcinoma(PHC group).Among LC cases,we classified 27 as HBV-related compensated cirrho-sis(HBV-CC)and 98 as HBV-related decompensated cirrhosis(HBV-DC).We collected clinical data from each group af-ter definitive diagnosis and prior to antiviral therapy,and measured serum GP73 levels by using chemiluminescent en-zyme immunoassay.We used multivariate binary Logistic regression to analyze the effects of GP73 on PHC and HBV-DC.We plotted receiver operating characteristic(ROC)curves to assess the diagnostic value of GP73 for PHC and HBV-DC.Results Serum GP73 levels increased successively in the CHB group,LC group,and PHC group(all P<0.05).The se-rum GP73 level in the HBV-DC group was higher than that in the HBV-CC group(P<0.05).Elevated levels of GP73(OR=1.006,95%CI:1.001-1.011),alpha-fetoprotein(AFP)(OR=1.021,95%CI:1.013-1.029),and protein induced by vitamin K absence Ⅱ(PIVKA Ⅱ)(OR=1.008,95%CI:1.003-1.012)were identified as independent risk factors for the development of PHC(all P<0.05).Based on the results of the multivariate binary Logistic regression analysis,we constructed a diagnostic model for PHC using GP73,AFP,and PIVKA Ⅱ(GAP model).The formula was as follows:logit(P)=0.006×GP73+0.021×AFP+0.007×PIVKA Ⅱ-4.103.We found that the area under the curve(AUC)of the GAP model in diagnosing PHC was significantly higher than that of GP73,AFP,or PIVKA-Ⅱ alone(all P<0.05).The elevated GP73 level(OR=1.024,95%CI:1.011-1.036)and decreased hemoglobin(Hb)(OR=0.932,95%CI:0.897-0.967)levels were the independent risk factors for the occurrence of HBV-DC(both P<0.05).We constructed a diagnostic model for HBV-DC using GP73 and Hb(GH model).The formula was as follows:logit(P)=0.023×GP73-0.071×Hb+6.149.We found that the AUC of the GH model in diagnosing HBV-DC was significantly higher than that of GP73 or Hb alone(both P<0.05).Conclusions Serum GP73 levels progressively increase with the progression of chronic HBV infection-related liver disease.Serum GP73 levels can enhance the diagnostic value of other markers for PHC and HBV-DC.
Keywords：hepatitisliver cirrhosishepatocellular carcinomagolgi protein 73hepatitis B virus
Publication Date：2025-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 100-103,108 )