Meta-analysis of relationship between type 2 diabetes mellitus and small intestinal bacterial overgrowth
YIN Wenqin
SHI Gengsheng
LIN Song
ZHANG Linluo
LUO Jing
Abstract：Objective To systematically analyse the relationship between type 2 diabetes mellitus(T2DM)and small intestinal bacterial overgrowth(SIBO).Methods A computerised search of PubMed,EMBASE,Web of Science,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,and VIP Database for literature on T2DM and SIBO was conducted from the time of library construction to August 2024,and the literature was screened ac-cording to the established inclusion and exclusion criteria.Meta-analysis of the included literature was performed to com-pare the risk of SIBO between patients with T2DM and healthy controls.To explore sources of heterogeneity,subgroup analyses of study design,continent of study population and study quality were performed.Results A total of 18 publica-tions with 5,694 study subjects were included.Meta-analysis results showed the risk of SIBO in patients with T2DM in-creased in comparison with that of the healthy controls(OR=3.18,95%CI:2.24-4.53,P<0.001).Subgroup analyses showed that patients with T2DM had an increased risk of SIBO in case-control studies(OR=6.56,95%CI:3.96 to 10.86,P<0.001),as well as in cross-sectional studies(OR=2.05,95%CI:1.38 to 3.06,P<0.001);and T2DM pa-tients had a higher risk of SIBO in case-control studies than in cross-sectional studies;Asian T2DM patients had an in-creased risk of SIBO(OR=5.85,95%CI:3.09 to 11.08,P<0.001),as well as European T2DM patients(OR=2.58,95%CI:1.41 to 4.73,P=0.002),whereas there was no significant difference in the risk of SIBO in North American T2DM patients(OR=1.67,95%CI:0.77 to 3.62,P=0.193),and the risk of SIBO was higher in Asian T2DM patients than in European patients;the risk of SIBO increased in T2DM patients in high-quality studies(OR=5.06,95%CI:2.40 to 10.66,P<0.001),the risk of SIBO increased in T2DM patients in low-quality studies(OR=2.72,95%CI:1.82 to 4.09,P<0.001),and the risk of SIBO in T2DM patients in the high-quality studies was higher than that in low-quality studies.Conclusion The risk of SIBO was higher in T2DM patients than in the general healthy population,and the risk of SIBO was higher in Asian T2DM patients than in European patients.
Keywords：small intestinal bacterial overgrowthtype 2 diabetes mellitusMeta-analysis
Publication Date：2025-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 91-95 )