Prevalence survey and related risk factor analysis for vitamin D deficiency of patients in a Grade-A tertiary hospital at Qianxinan Prefecture of Guizhou Province

WU Linli; BAO Linchun; LI Wanlin; HUA Dong; FENG Ning

doi:10.3969/j.issn.1002-266X.2025.01.017

Abstract：Objective To investigate the prevalence of vitamin D deficiency among patients at Qianxinan People's Hospital in Guizhou,coupled with an analysis of its associated influencing factors,which can provide a scientific founda-tion for the formulation of effective public health strategies.Methods This study retrospectively collected data from 105,296 patients who underwent serum 25-hydroxyvitamin D[25(OH)D]level testing during their visits to Qianxinan People's Hospital as the study subjects.The serum 25(OH)D levels were detected by electrochemiluminescence method,and based on the"Consensus on the Clinical Application of Vitamin D and Its Analogues",the study subjects were catego-rized into three groups:individuals with sufficient vitamin D,those with vitamin D insufficiency,and those with vitamin D deficiency.Data on gender,age,hospitalization status,and season of visit were collected.The serum 25(OH)D levels and vitamin D deficiency status of the subjects were compared.Binary Logistic regression analysis was performed to identify the factors influencing vitamin D deficiency among the study participants.Results The serum 25(OH)D level of 105,296 study subjects was 26.68(19.46,37.02)ng/mL;among them,28,298 cases(26.87％)had vitamin D deficiency,and 34,769 cases(33.02％)had vitamin D insufficiency.The serum 25(OH)D levels in male subjects were higher than those in female subjects,and the vitamin D deficiency rate was lower in males than in females(all P<0.05).Outpatients had a higher serum 25(OH)D level and a lower vitamin D deficiency rate compared with inpatients(both P<0.05).The serum 25(OH)D level decreased,and the vitamin D deficiency rate increased with increasing age.The highest 25(OH)D level and lowest deficiency rate were found in the 0-6 years group,while the lowest 25(OH)D level and highest deficiency rate were observed in the≥70 years group(both P<0.01).The 25(OH)D levels were lower in hospitalized patients in compari-son with the outpatient ones.The serum 25(OH)D level was the highest in summer,followed by autumn,spring,and win-ter.The vitamin D deficiency rate was the highest in winter,followed by spring,autumn,and summer(all P<0.05).The results of the binary Logistic regression analysis indicated that gender,age,hospitalization status,and season were all sig-nificant factors influencing vitamin D deficiency in the study subjects.Conclusions Vitamin D insufficiency and defi-ciency are prevalent among patients visiting Qianxinan People's Hospital.Gender,age,hospitalization status,and season are all factors that influence vitamin D deficiency.