Effects of vitamin D supplementation on lung function,immunoglobulin,serum Gal-3,IL-17A levels in children aged≥6 years with bronchial asthma
LIU Lihui
HUANG Wei
LI Mingli
ZHANG Congcong
Abstract：Objective To investigate the effects of vitamin D supplementation on lung function,immunoglobulin and serum galectin 3(Gal-3)and interleukin17A(IL-17A)levels in children≥6 years old with bronchial asthma.Methods A total of 150 children≥6 years old with bronchial asthma treated in the First Hospital of Qinhuangdao City from December 2019 to December 2022 receiving routine treatment were selected as the control group;150 children≥6 years old with bron-chial asthma who were treated in the First Hospital of Qinhuangdao City from May 2023 to May 2024 and received vitamin D supplement therapy were selected as the study group.The clinical efficacy,the number of acute asthma attacks and the dis-appearance time of symptoms and signs were compared between the two groups.The pulmonary function[forced vital ca-pacity(FVC),forced expiratory volume in the first second(FEV1),FEV1/FVC,maximum peak expiratory flow rate(PEF)],immunoglobulin[immunoglobulin E(IgE),immunoglobulin A(IgA),and immunoglobulin G(IgG)],exhaled nitric oxide(FeNO)and serum Gal-3 and IL-17A levels were compared in the two groups before and after 3 months of treat-ment.Results The study group had higher total effective rate than the control group(94.67%vs 84.00%)(P<0.05).The number of acute attacks of asthma in the study group was smaller,and the disappearance time of symptoms and signs was shorter(both P<0.05).FVC,FEV1,FEV1/FVC and PEF were higher after treatment,and those in the study group were higher than those in the control group(all P<0.05).After treatment,the levels of IgE in both groups were lower than those before treatment,while the levels of IgA and IgG were higher than those before treatment;the study group was better than the control group(all P<0.05).After treatment,the levels of FeNO,Gal-3,and IL-17A in both groups were lower than those before treatment,and the levels in the study group were lower than those in the control group(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Vitamin D supplementation can improve the lung function,immunoglobulin,serum Gal-3 and IL-17A levels in children≥6 years old with bronchial asthma,reduce the body's inflammatory response,and improve the therapeutic effect.
Keywords：bronchial asthmavitamin Dimmunoglobulingalectin 3children
Publication Date：2024-12-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 25-28 )