Relationships of serum BCAAs and SFRP5 levels with postnatal abnormal glucose metabolism in patients with gestational diabetes mellitus
WANG Jinfeng
XU Jing
LI Xiaohong
LU Caihua
Abstract：Objective To investigate the relationships between serum branched chain amino acids(BCAAs)and se-creted frizzled-related protein 5(SFRP5)levels and postnatal abnormal glucose metabolism(AGM)in patients with gesta-tional diabetes mellitus(GDM).Methods Totally 204 patients with GDM were selected as the GDM group and 102 healthy pregnant women who delivered in our hospital in the same time period were selected as the control group,and the patients with GDM were divided into the AGM group and the non-AGM group according to the occurrence of AGM in the first three months after delivery.Serum BCAAs(valine,isoleucine,leucine)levels were measured by amino acid analyzer assay and serum SFRP5 level was measured by enzyme-linked immunosorbent assay.A multifactorial unconditional Logis-tic regression model was established to determine the factors of postnatal AGM in GDM patients with postnatal AGM as the dependent variable,and receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of se-rum BCAAs and SFRP5 levels.Results Compared with the control group,serum valine,isoleucine,leucine,and BCAAs levels increased and SFRP5 level decreased in the GDM group(all P<0.05).At 3-month follow-up,the incidence of postpartum AGM was 31.86%(65/204)in 204 GDM patients.Compared with the non-AGM group,serum valine,iso-leucine,leucine,and BCAAs levels increased and SFRP5 level decreased in the AGM group(all P<0.05).Family histo-ry of diabetes mellitus,increased OGTT 2 h glucose,and increased BCAAs were independent risk factors for postpartum AGM in GDM patients,and increased SFRP5 was an independent protective factor(all P<0.05).The area under the curve of serum BCAAs combined with SFRP5 level in predicting postpartum AGM in GDM patients was 0.861,which was greater than that(0.783 and 0.787)of serum BCAAs and SFRP5 levels alone(both P<0.05).Conclusion The elevat-ed serum BCAAs level and reduced SFRP5 level in GDM patients were independently associated with postnatal AGM,and serum BCAAs combined with SFRP5 levels had a high predictive value.
Keywords：gestational diabetes mellitusbranched chain amino acidssecreted frizzled-related protein 5postna-tal abnormal glucose metabolism
Publication Date：2024-12-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 20-24 )