Expression changes of cell division cycle 25C protein and mRNA in hepatocellular carcinoma tissues
LIU Hailong
ZHANG Qihui
LI Yanfei
ZHANG Yaoyao
CHAO Naixia
MO Farong
Abstract：Objective To observe the expression changes of cell division cycle 25C protein and mRNA in hepatocel-lular carcinoma tissues.Methods Forty patients with hepatocellular carcinoma confirmed by pathological examination underwent surgery,and hepatocellular carcinoma tissues and their adjacent tissues were collected during surgery.The ex-pression of CDC25C protein and mRNA in hepatocellular carcinoma and adjacent tissues were detected by in situ hybridiza-tion and immunohistochemistry,respectively.Results The relative expression levels of CDC25C protein in hepatocellu-lar carcinoma tissues and adjacent tissues were 0.392±0.075 and 0.099±0.043,respectively,with a significant differ-ence between them(P<0.05).The relative expression levels of CDC25C mRNA in hepatocellular carcinoma tissues and adjacent tissues were 0.122±0.014 and 0.062±0.017,respectively,with a significant difference between them(P<0.05).Compared with patients with grade≤2,patients with grade>2 had higher expression levels of CDC25C protein and mRNA in hepatocellular carcinoma tissues(both P<0.05).Compared with patients without liver cirrhosis,patients with liver cirrhosis had higher expression levels of CDC25C protein and mRNA in hepatocellular carcinoma tissues(both P<0.05).The expression of CDC25C protein in hepatocellular carcinoma tissues was higher in females than in males(P<0.05).Conclusion CDC25C protein and mRNA are highly expressed in hepatocellular carcinoma tissues,and CDC25C may promote the development and progression of hepatocellular carcinoma.
Keywords：cell division cycle 25Cliver neoplasmsprimary liver carcinomahepatocellular carcinoma
Publication Date：2024-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )