Relationship between serum 5-HT and NGF levels and recurrence after selective resection of dorsal penile nerve in patients with primary premature ejaculation
LI Hongbin
HOU Lin
XING Jiandong
FENG Dong
FAN Maoyu
Abstract：Objective To investigate the relationships between the serum 5-hydroxytryptamine(5-HT)and nerve growth factor(NGF)levels and recurrence after selective resection of the dorsal nerve of the penis in patients with primary premature ejaculation.Methods Totally 200 patients who underwent selective resection of the dorsal nerve of the penis were selected as the study subjects.Six months after surgery,they were divided into the recurrent group(n=23)and non-recurrent group(n=177)based on whether the patients had recurrence or not.The clinical data,serum levels of 5-HT and NGF were compared between two groups.The correlations between 5-HT and NGF with the Chinese Index of Premature Ejaculation-5 questionnaire(CIPE-5),International Index of Erectile Function-5(IIEF-5)score,and ejaculation latency time(IELT)were analyzed.Factors affecting postoperative recurrence were analyzed,and we constructed a nomogram model to evaluate the consistency between the postoperative recurrence predicted by model containing serum indicators and the actual observation,and used the decision curve to evaluate the clinical benefit of the model.Results The serum 5-HT level,IELT,and CIPE-5 score in the recurrent group were lower than those in the non-recurrent group at 3 months af-ter surgery,while the NGF level was higher than that in the non-recurrent group(all P<0.05).The serum 5-HT level was positively correlated with CIPE-5 score and IELT in patients with primary premature ejaculation before surgery,1 months after surgery,and 3 months after surgery(all P<0.05),but was not related to IIEF-5 score(P>0.05);the serum NGF level was negatively correlated with CIPE-5 score and IELT(all P<0.05),but was not related to IIEF-5 score(P>0.05).IELT,CIPE-5 score,serum 5-HT,and NGF levels at 3 months after surgery were independent influencing factors for post-operative recurrence in patients with primary premature ejaculation(all P<0.05).The consistency index of the nomogram model in predicting postoperative recurrence related factors in patients with primary premature ejaculation was 0.775(95%CI=0.674-0.802).The decision curve showed that when the model containing serum indicators predicted postopera-tive recurrence in patients with primary premature ejaculation in the range of 0.2-0.85,it could provide additional clinical benefits.Conclusion The serum 5-HT level decreases and NGF level increases 3 months after selective resection of the dorsal penile nerve,which has certain reference value for predicting postoperative recurrence in patients with primary pre-mature ejaculation.
Keywords：primary premature ejaculationdorsal penile nerve selective excisionrecurrence5-HTnerve growth factor
Publication Date：2024-07-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 30-34 )