Construction and efficacy validation of diagnosis scoring model of early Parkinson's disease
WANG Guohong
WANG Yuting
WANG Yaqi
HU Wanhua
XIA Shiyong
Abstract：Objective To construct a diagnostic scoring model for early Parkinson's disease(PD)and to verify its efficacy.Methods Seventy-five patients with early PD and 75 gender-age matched healthy volunteers were selected and randomly divided into the verification group(38 patients with early PD and 37 healthy volunteers)and training group(37 patients with early PD and 38 healthy volunteers).Medical records of subjects were collected.The least absolute shrink-age and selection operator(LASSO)was used to determine the optimal parameters through 10-fold cross-validation;the rel-evant diagnostic factors were screened from the relevant data of the training group,and the diagnostic scoring model was constructed according to each factor coefficient.The nomogram was constructed by Logistic regression;the receiver operat-ing characteristic curve(ROC)was drawn,and the diagnostic efficiency and fit degree of the model were evaluated by the area under the curve(AUC)and the calibration curve.Results There was no significant difference in relevant data be-tween the training group and the verification group(P>0.05).In the training group,the best parameter λ=0.052 was de-termined by LASSO algorithm,and seven indexes of identification ability were screened out.The diagnosis scoring model formula=-1.048+0.961×RBDSQ score+0.079×HAMA-14 score-0.0002×NSE-0.011×VEGF-0.001×uric ac-id-0.046×FA+0.003×DFV.Multivariate Logistic regression analysis confirmed that the seven selected indicators could be used as independent diagnostic factors for early PD patients.In the verification group,the area under the curve of this diagnostic scoring model in diagnosing early PD patients was 0.91,which was higher than that of seven factors alone;the fitting curve showed that the model had good goodness of fit.Conclusion Based on RBDSQ scoring,HAMA-14 scoring,VEGF,FA,NSE,uric acid and DFV,the diagnostic scoring model of early PD has been constructed,and the model has relatively high diagnostic efficiency.
Keywords：Parkinson's diseaseearly stageleast absolute shrinkage and selection operatordiagnostic scoring modeldiagnostic efficiency
Publication Date：2024-07-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 15-19 )