Changes of serum INHA and GCD59 levels in patients with gestational diabetes and their predictive efficacy for adverse pregnancy outcomes

LU Sha; LI Ruihua; SHEN Ran; WANG Fang; ZHAO Ying

doi:10.3969/j.issn.1002-266X.2023.36.003

Abstract：Objective To observe the changes of serum inhibin A(INHA)and glycated cluster of differentiation 59(GCD59)levels in patients with gestational diabetes mellitus(GDM),and to analyze their predictive efficacy for adverse pregnancy outcomes.Methods Ninety-seven pregnant women with GDM(observation group)and 100 healthy pregnant women in the same period(control group)were selected.The serum INHA and GCD59 levels in both groups were detected by enzyme-linked immunosorbent assay.According to the occurrence of adverse pregnancy outcome,the observation group was divided into adverse group(31 cases)and good group(66 cases).Univariate and multivariate Logistic regression anal-yses were used to analyze the influencing factors of adverse pregnancy outcome in pregnant women with GDM.Receiver op-erating characteristic(ROC)curve was drawn to analyze the predictive efficacy of serum INHA and GCD59 levels for ad-verse pregnancy outcomes in GDM patients.Results Compared with the control group,serum INHA and GCD59 levels increased in the observation group(both P＜0.05).Significant differences were found in the INHA,GCD59,HbA1c,and HOMA-IR between the adverse group and the good group(all P＜0.05).Elevated INHA,GCD59,and HOMA-IR were in-dependent risk factors for adverse pregnancy outcomes in patients with GDM(all P＜0.05).The best cut-off value of serum INHA level in predicting adverse pregnancy outcome in GDM patients was 1 209.95 pg/mL,and the area under the curve(AUC)was 0.788(0.693-0.864),the sensitivity,specificity,and Youden index were 90.32%,59.09%,and 0.494,respectively.The best cut-off value of serum GCD59 level in predicting adverse pregnancy outcomes in GDM patients was 3.60 ng/mL,AUC was 0.785(0.690-0.862),sensitivity,specificity,and Youden index were 90.30%,51.52%,and 0.418,respectively.The AUC of serum INHA and GCD59 levels in predicting the adverse pregnancy outcomes in GDM patients was 0.897(0.819 to 0.949),and the sensitivity,specificity,and Youden index were 83.97%,89.39%,and 0.733,respectively.Conclusion Elevated serum INHA and GCD59 levels in patients with GDM are risk factors for ad-verse pregnancy outcome in patients with GDM,and detection of the two indicators is helpful in predicting the adverse preg-nancy outcome in patients with GDM.