Relationships between serum Beclin1 and SIRT6 levels and postoperative ischemia-reperfusion injury in STEMI patients
CHEN Zuoqiang
LI Zhoujian
Yiparguli Abra
GONG Lihua
ZHANG Huimin
Abstract：Objective To investigate the relationships between serum Beclin1(BECN1)and silent information regu-lator transcript 6(SIRT6)levels and postoperative ischemia-reperfusion injury(IRI)in patients with ST-segment elevation myocardial infarction(STEMI).Methods Totally 150 STEMI patients were selected as the STEMI group,and then were divided into the IRI and non-IRI groups according to whether IRI occurred after percutaneous coronary intervention(PCI),and meanwhile,68 healthy volunteers with physical examination were selected as the control group during the same period.Serum BECN1 and SIRT6 levels were measured by enzyme-linked immunosorbent assay.We analyzed the factors influencing postoperative IRI in STEMI patients,and receiver operating characteristic(ROC)curves of serum BECN1 and SIRT6 levels were drawn.Results Compared with the control group,the serum BECN1 and SIRT6 levels were reduced in the STEMI group(both P<0.05).The incidence of IRI after PCI in 150 STEMI patients was 38.00%(57/150).Multifactorial Logistic regression analysis showed that increasing age(OR=1.094,95%CI:1.019 to 1.174)and increased albumin(OR=0.826,95%CI:0.723 to 0.943)and BECN1(OR=0.880,95%CI:0.830 to 0.933)and SIRT6(OR= 0.338,95%CI:0.204 to 0.558)were independent risk and protective factors for postoperative IRI in STE-MI patients(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of the combined serum BECN1 and SIRT6 levels(AUC=0.872,95%CI:0.808 to 0.921)in predicting postoperative IRI in STEMI patients was greater than that of BECN1(AUC=0.782,95%CI:0.707 to 0.845)or SIRT6(AUC= 0.783,95%CI:0.708 to 0.846)alone(both P<0.05).Conclusions Decreased serum BECN1 and SIRT6 levels in STEMI patients are closely related to postoperative IRI,which have a certain predictive value for postoperative IRI in STEMI patients.Serum BECN1 and SIRT6 levels are of high value in predicting postoperative IRI in STEMI patients,and may become auxiliary predictors of postoperative IRI in STEMI patients.
Keywords：ST-segment elevation myocardial infarctionBeclin1silent information regulator transcript 6percu-taneous coronary interventionischemia-reperfusion injury
Publication Date：2023-12-05
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 6-10 )