Expression changes and clinical significance of Ki-67,Bcl-2,and p53 in endometrial cancer tissues

WANG Hui; HAN Chen; DONG Xinqian; SHENG Zhongnan; LI Tongmin; LI Zhenzhen; WANG Hengxiao

doi:10.3969/j.issn.1002-266X.2018.21.006

Abstract：Objective To investigate the expression changes of Ki-67,Bcl-2 and p53 in the endometrial cancer tis-sues and their clinical significance. Methods Sixty cases of endometrial carcinoma tissues removed from the surgery were collected as the observation group. The endometrial tissues from 20 patients with uterine fibroids,20 patients with simple hyperplasia,and 10 patients with complicated hyperplasia were collected as the control group. The expression of Ki-67, Bcl-2,and p53 was measured and compared by immunohistochemistry staining between two groups. The relationship be-tween the expression of Ki-67,Bcl-2 and p53 and clinicopathological features of patients with endometrial carcinoma was analyzed. Results The positive expression rates of ki-67,Bcl-2 and p53 in the observation group were significantly higher than those in the control group (P < 0. 05). The expression of Ki-67 in the endometrial carcinoma tissues was positively correlated with clinical stage,myometrial invasion,lymph node metastasis,and degree of differentiation (P < 0. 05), whereas was not correlated with age (P > 0. 05);the expression of Bcl-2 was positively correlated with clinical stage,and differentiation degree (both P < 0. 05),whereas was not correlated with age,muscle layer infiltration,or lymph node me-tastasis (all P > 0. 05);the expression of p53 in the endometrial carcinoma tissues was positively correlated with clinical stage,lymph node metastasis,and degree of differentiation (P < 0. 05),but was not correlated with age or myometrial in-vasion (both P > 0. 05). Conclusion Ki-67,Bcl-2,and p53 protein are highly expressed in the endometrial carcinoma tissues,which are all related to clinical stage and differentiation degree.