Changes of endogenous gas hydrogen sulfide levels and genesis mechanism in Graves'disease
WANG Xinyu
LIANG Qian
YAO Weili
OU Huiting
LYU Lingbo
Abstract：Objective To investigate the level and role of endogenous gaseous hydrogen sulfide (H2S) in patientswith diffuse toxic goiter (Graves disease,GD),and to explore its generative mechanism.Methods The serum of 20 GD patients without treatment (untreated group),20 patients with remission of GD (treatment remission group,GD) and 20 patients with thyroid nodules (control group) was collected,and we measured the concentrations of H2S by spectrophotometry.At the same time,8 patients in each group were selected and their thyroid tissues were taken.RT-PCR-was used to detect the mRNA levels of cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE).Results Compared with the control group,the concentration of H2S decreased in the untreated group (P ＜ 0.05);the concentration of H2S increased in the treatment remission group as compared with that of the untreated group (P ＜ 0.05).CBS mRNA expression was found in the control group,but it decreased in the thyroid tissues of the untreated group.The CBS mRNA expression increased in the thyroid tissues of the treatment remission group (all P ＜ 0.05),but CSE mRNA was not expressed.Conclusions The level of endogenous H2S in patients with GD decreases,which may play an anti-inflammatory role in the pathogenesis of GD.The enzyme that catalyzes the synthesis of H2S in thyroid tissues is mainly CBS,not CSE.
Keywords：toxic diffuse goiterendogenous gas hydrogen sulfidecystathionine-β-synthasecystathionine-γ-lyase
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 21-23 )