Change and significance of laterality of attention networks in patients with hyperthyroidism
OU Nannan
ZU Meidan
BAI Tongjian
WEI Qiang
TIAN Yanghua
DAI Fang
WANG Kai
Abstract：Objective To investigate the changes of the laterality of attention networks in patients with hyperthyroid -ism and its mechanism.Methods Twenty-three hyperthyroid patients(hyperthyroid group)and 21 health controls(con-trol group)were selected.Digit span forward(DSF)and digit span backward(DSB)were performed to assess the atten-tion,working memory and executive function.The Hamilton anxiety(HAMA)scale and Hamilton depression(HAMD) scale were performed to evaluate the anxiety and depression situation.The lateralized attention network test(LANT)was used to detect reaction time(RT)of both visual fields in different target types and cue types;according to RTs in different condition,we assessed the efficiency of the network.Pearson correlation analysis was used to analyze the relationship be-tween neuropsychological scales,thyroid hormone level, and the orienting network in visual field.Results DSF scores were lower,HAMD and HAMA scores were higher in the hyperthyroid group as compared with those of the control group(P<0.05).There were no significant differences in the MMSE scores or DSB scores between the two groups(P>0.05). There was significant difference in RT under different target types in both visual fields between the two groups(all P<0.05),and the order was RT na >RT double cue>RT valid cue.There was significant difference in RT under different cue types,and the order was RT incongruent >RT congruent(all P<0.05).No statistical differences were found in the network efficiency of alerting, orienting and executive control between both visual fields in the hyperthyroid group(P>0.05).Orienting efficiency of the right visual field was higher than that of the left visual field in the control group(P<0.05).No statistical differences were found in the network efficiency of alerting and executive control between both visual fields in the control group(both P>0.05).The orienting efficiency of the right visual field was negatively correlated with the level of FT3(r=-0.463, P=0.046).Conclusion The advantage of left hemisphere lateralization disappears, which may be related to abnormal thyroid hormone level.
Keywords：hyperthyroidismlateralized attention network testcerebral hemispheric asymmetrycerebral attention functionlaterality of cerebral hemisphere
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )