Expression of TRAP1 and BRAFV600E gene mutation in papillary thyroid cancer and its correlation analysis
LIANG Huiling
HE Xiaoyan
YANG Wenxiu
WANG Long
YANG Yong
Abstract：Objective To study the expression of tumor necrosis factor receptor-associated factor 1 (TRAP1) and V-raf murine sarcoma viral oncogene homolog B1 V600E gene (BRAFV600E gene) mutation in the papillary thyroid cancer (PTC) and to analyze the correlation between TRAP1 and BRAFV600E gene mutation.Methods One hundred cases of PTC tissues (group A),38 cases of thyroid adenoma tissues (group B),and 38 cases of nodular goiter tissues (group C) were selected.TRAP1 protein expression and BRAFV600E gene mutation in each group were observed,and then we analyzed the correlation between TRAP1 expression and BRAFV600E gene mutation as well as its relationship with clinicopathological characteristics of PTC.Results In the groups A,B,and C,the positive rates of TRAP1 were 71％,13.16％,and 10.53％,respectively,and the mutation rates of BRAFV600E gene were 52％,0,and 0,respectively;significant difference was found between group A and group B,and between group A and group C,all P ＜ 0.05.BRAFV600E gene mutation was associated with the age and tumor diameter (both P ＜ 0.05).The TRAP1 expression was positively correlated with BRAFV600E gene mutation in the group A (r =0.445,P =0.000).Conclusion The positive rate of TRAP1 and the mutation rate of BRAFV600E gene increase in the PTC tissues,the BRAFV600E gene mutation is closely related to the high expression of TRAP1,and both of them may participate in the occurrence and development of PTC.
Keywords：papillary thyroid carcinomatumor necrosis factor receptor-associated factor 1 (TRAF1)V-raf murine sarcoma viral oncogene homolog B1V600E gene
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 22-25 )