Correlation between serum sfrp5 and left ventricular hypertrophy in patients with T2DM complicated with different classifications of hypertension
ZHANG Xin
LI Baoxin
ZHANG Yunliang
CHANG Wenlong
WANG He
MA Shuang
GUO Shuqin
Abstract：Objective To investigate the changes of serum secreted frizzled-related protein-5 (sfrp5) and its correlation with left ventricular hypertrophy in patients with type 2 diabetes mellitus (T2DM) and different classifications of hypertension. Methods A total of 200 subjects were divided into the normal control group (NC group), T2DM without hypertension group (DS group), T2DM with grade 1 hypertension group (H1 group), T2DM with grade 2 hypertension group (H2 group), and T2DM with grade 3 hypertension group (H3 group).We determined the levels of serum sfrp5 and used the echocardiogram to ob-serve the changes of cardiac structure and function in each group .Results The early diastolic and late diastolic peak velocity ratio (E/A) and sfrp5 decreased in the DS, H1, H2, and H3 groups as compared with that of the NC group (both P<0.05). E/A and sfrp5 were significantly lower in the H1, H2, and H3 groups than in the DS group, and gradually decreased with the in-crease of blood pressure classification (both P<0.05).The left ventricular mass index (LVMI) was higher in the DS, H1, H2, and H3 groups than in the NC group (all P<0.05).The LVMI in the H1, H2, and H3 groups were greater than that in the DS group, and the LVMI gradually increased with the increase of blood pressure (all P<0.05).Multiple linear regression analysis showed that serum sfrp5 level was negatively correlated with LVMI, SBP, and DBP (r=-0.260,-0.160,-0.290;P<0.05). Conclusions With the increase of blood pressure classification , the serum sfrp5 decreases but the LVMI increases .Sfrp5 plays an important role in the change of left ventricular hypertrophy in patients with T2DM and hypertension.
Keywords：diabetes mellitustype 2hypertensionleft ventricular hypertrophydifferent classificationsecreted frizzled-related protein-5
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )