Application value of detection of peripheral MSA, CEA, and NLR in diagnosis and differential diagnosis of small cell lung cancer
TAN Liming
ZHENG Wei
FU Huiying
MENG Yimei
GUAN Xiaolin
WU Sifan
LONG Tingting
WANG Qiaohua
WU Yang
ZENG Tingting
TIAN Yongjian
YU Jianlin
CHEN Juanjuan
LI Hua
CAO Liping
Abstract：Objective To observe the application value of detection of serum anti-spindle antibodies (MSA),carcinoembryonic antigen (CEA),whole blood neutrophils/lymphocytes (NLR) in diagnosis and differential diagnosis of small cell lung cancer (SCLC).Methods Fifty-three patients with SCLC (SCLC group),33 patients with lung adenocarcinoma (LAC) (LAC group),29 patients with lung squamous cell carcinoma (LSC) (LSC group),16 patients with gastric carcinoma (GC) (GC group),14 patients with hepatic carcinoma (HC) (HC group),13 patients with colorectal cancer (CC) (group CC),12 patients with nasopharyngeal carcinoma (NC) (NC group),and 45 healthy controls (control group) were selected.Serum MSA was detected by indirect immunofluorescence method.Serum CEA was detected by chemiluminescence.Whole blood NLR was measured by electrical impedance method.The sensitivity and specificity of single and combined detection of serum MSA,CEA and whole blood NLR were analyzed.Results Compared with the other groups,the positive rate of serum MSA in the SCLC group was high.Compared with the SCLC group,the positive rates of serum CEA and whole blood NLR in the LAC group were high,while the positive rates of CEA and whole blood NLR in the control group were lower (all P ＜ 0.05).The sensitivity of detecting NLR alone in diagnosis of SCLC was the highest (43.40％),while specificity of detecting MSA alone was the highest (96.58％).The sensitivity of combined detection of MSA + CEA + NLR in diagnosis of SCLC was the highest (in parallel,81.84％),and the specificity was the highest (in series,100.00％).MSA and CEA had higher consistency (κ =0.654),and MSA was moderately consistent with NLR (κ=0.451).Conclusion The combined detection of serum MSA,CEA,and whole blood NLR is helpful for the diagnosis and differential diagnosis of SCLC.
Keywords：small cell lung canceranti-spindle antibodycarcinoembryonic antigenneutrophilslymphocytes
Publication Date：2017-12-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 13-16 )