Relationship between rs2208454 single nucleotide polymorphism of MACROD2 gene and ischemic stroke in Zhuang population of Guangxi Zhuang autonomous region
JIANG Dongdong
LUO Man
Abstract：Objective To explore the relationship between single nucleotide polymorphism (SNP)of rs2208454 in MACROD2 gene and ischemic stroke (IS)in Zhuang population of Guangxi Zhuang autonomous region. Methods The rs2208454 single nucleotide of MACROD2 gene was detected by SNaPshot technique in 101 cases of Guangxi Zhuang IS pa-tients (IS group)and 104 healthy subjects (control group). Results The GG,GT,TT genotypes and G,T allele distri-bution of rs2208454 locus of MACROD2 gene were not statistically different between these two groups (all P > 0. 05). The rs2208454 locus SNP of MACROD2 gene was not associated with the risk of IS in dominant (TT + GT and GG),recessive (TT and GT + GG)and additive (TT and GG)genetic models (all P > 0. 05). Conclusion The rs2208454 locus SNP of MACROD2 gene has no correlation with the pathogenesis of IS in Guangxi Zhuang population.
Keywords：MACROD2 geneMACROD2 gene rs2208454single nucleotide polymorphismstrokeischemic stroke
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 11-13 )