Expression changes of Twist and E-cadherin in oral squamous cell carcinoma
WANG Chenfei
FENG Guijuan
WANG Jihua
FENG Xingmei
Abstract：Objective To explore the expression changes of the transcription factor Twist and the E-cadherin in the o-ral squamous cell carcinoma (OSCC)tissues and to investigate the clinical significance. Methods The immunohisto-chemical SP method was used to detect the expression levels of the Twist and E-cadherin in 65 cases of OSCC tissues and 45 cases of oral normal mucosa tissues. In addition,the relationship between the expression of Twist/ E-cadherin and the clinicpathologic characteristics was analyzed,and the Spearman was used to explore the correlation between the Twist and E-cadherin in OSCC tissues. Results The positive expression rates of Twist in the OSCC tissues and oral normal mucosa tissues were 72. 31% (47 / 65)and 11. 11% (5 / 45),respectively (P < 0. 05). The positive expression rates of E-cadher-in in the OSCC tissues and oral normal mucosa tissues were 23. 08% (19 / 65)and 86. 67% (39 / 45),respectively (P <0. 05). The Twist and E-cadherin expression levels in the OSCC tissues were related with the lymph node metastasis and the clinical stages (both P < 0. 05),but were not related with the gender,age,differentiation degree and the type (all P >0. 05). The expression of Twist and E-cadherin was negatively correlated in the OSCC tissues (r = - 0. 412,P < 0. 05). Conclusions The transcription factor Twist is up-regulated and E-cadherin is down-regulated,both of them play a critical role in the occurrence and malignant progression of OSCC.
Keywords：oral squamous cell carcinomatranscription factor TwistE-cadherin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 28-30 )