Changes in levels of serum GRO-α and MRpro-ADM in patients with acute exacerbation of chronic obstructive pulmonary disease
WANG Yan'e
YU Bo
FENG Lijuan
AI Fen
Abstract：Objective To observe the changes in levels of the serum growth-regulated oncogene-α(GRO-α) and mid-regional fragment of pro-adrenomedullin (MRpro-ADM) in patients with acute exacerbation of chronic obstructive pul-monary disease(AECOPD) and its clinical significance.Methods A total of 79 patients with AECOPD(AECOPD group) were collected. At the same time,60 patients with stable COPD (stable COPD group) and 60 healthy volunteers (control group) were randomly selected. The serum GRO-α levels of the three groups were detected by the enzyme-linked immunosorbent assay,and MRpro-ADM levels of three groups were detected by the time-resolved immunofluorescence as-say. And the forced expiratory volume in one second (FEV1 ),forced vital capacity (FVC),FEV1/FVC were measured. The correlation between serum GRO-α,MRpro-ADM,and lung function such as FEV1 ,FVC,and FEV1/FVC were ana-lyzed by Pearson product moment correlation analysis. The diagnostic value of GRO-α,MRpro-ADM for AECOPD were an-alyzed by the receiver operating characteristic(ROC) curve.Results The serum levels of GRO-α and MRpro-ADM in the AECOPD group and stable COPD group were higher than those of the control group,and the AECOPD group was higher than the stable COPD group (both P<0. 05). Compared with the control group,the levels of FEV1,FVC,and FEV1/FVC in the AECOPD group and stable COPD group were lower,and the AECOPD group was lower than the stable COPD group (all P<0. 05 ). The serum level of GRO-α was negatively correlated with FEV1 ,FVC,and FEV1/FVC (r =-0. 471,-0. 509,and -0. 511 respectively;all P<0. 05). The serum level of MRpro-ADM was negatively correlated with FEV1 ,FVC,and FEV1/FVC (r= -0. 539,-0. 517,and -0. 498;all P<0. 05). The area under the ROC curve (AUC)of serum GRO-α for predicting AECOPD was 0. 854,the best cut-off value was 109. 34 ng/L,and the sensitivity and the specificity were separately 0. 82 and 0. 91 with accuracy of 0. 83. The AUC of serum MRpro-ADM for predicting AECOPD was 0. 808,the best cut-off value was 1. 28 nmol/L,and the sensitivity and the specificity were 0. 75 and 0. 82, respectively,with the accuracy of 0.77.Conclusion The serum levels of GRO-α and MRpro-ADM in patients with AECO-PD significantly increase,which can be used as important markers for clinical diagnosis of AECOPD.
Keywords：acute exacerbation of chronic obstructive pulmonary diseasegrowth-regulated oncogene-αmid-regional fragment of pro-adrenomedullinforced expiratory volume in first secondforced vital capacity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )