Clinical value of serum TIMP-4 in early diagnosis and prognosis of elderly patients with chronic heart failure
HUANG Yijun
ZHENG Yin
LI Wei
GAO Zhao
LU Shaoquan
LI Yunqian
Abstract：To explore the value of tissue inhibitor of metalloproteinase-4 (TIMP-4) in the early diagnosis and prognosis of elderly patients with chronic heart failure (CHF).Methods A total of 160 cases of elderly CHF patients (CHF group) including 68 cases of mild heart failure and 92 cases of severe heart failure were selected,meanwhile,another 40 health elderly people were selected as the control group.The left ventrieular end diastolic dimension (LVEDD) and left ventricular ejection fraction (LVEF) in the two groups were detected,the venous blood was extracted to determine the serum levels of TIMP-4 by double antibody sandwich enzyme-linked immunosorbent assay (ELISA).The early diagnosis value of serum TIMP-4 for CHF were analyzed by ROC curve.At 3,6,and 9 months after discharge,we reviewed the heart color Doppler ultrasound of elderly CHF patients and did the statistics of their heart events.Results The LVEDD in the CHF group was significantly higher than that of the control group,whereas LVEF and TIMP-4 were significantly lower than those of the control group,especially in the severe heart failure patients (all P ＜ 0.05);correlation analysis showed that the serum TIMP-4 level was positively correlated with LVEF (r =0.816,P ＜ 0.05),and was negatively correlated with LVEDD (r =-0.266,P ＜ 0.05).ROC curve analysis showed that the area under the curve (AUC) of serum TIMP-4 in diagnosis of elderly CHF patients was 0.916 (95％ CI:0.869-0.951) with the sensitivity of 77.0％ and the specificity of 92.0％.The cut-off value was 1.41 ng/mL.According to the cut-off value,we divided the elderly CHF patients in the high level TIMP-4 group (TIMP-4 ＞ 1.41 ng/mL,n =46) and low level TIMP-4 group (TIMP-4≤1.41 ng/mL,n =114).The 3-month cardiac event-free survival between the high level TIMP-4 group and low level TIMP-4 group was not significant different (P ＞ 0.05).The 6-month and 9-month cardiac event-free survival in the high level TIMP-4 group was significantly higher than that in the low level TIMP-4 group,and the difference between the two groups was statistically significant (P ＜ 0.05).Conclusion Serum TIMP-4 can be used as a predictor for the early diagnosis and prognosis of elderly patients with CHF.
Keywords：chronic heart failuretissue inhibitor of metalloproteinase 4elderly patientsdiagnosisprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 17-20 )