Changes in levels of serum Giα-2 and NGAL in type 2 diabetes combined with different classifications of hypertension
MA Shuang
LI Baoxin
ZHANG Yunliang
CHANG Wenlong
WANG He
ZHANG Xin
GUO Shuqin
Abstract：Objective To investigate the changes of serum inhibitory G-protein subunit Gi α-2 (Giα-2) and neutrophil gelatinase-associated lipocalin (NGAL) in type 2 diabetes combined with different classifications of hypertension and its clinical value.Methods Totally 197 patients with type 2 diabetes were selected.They were divided into 45 cases of simple diabetes (DS group), 47 cases of type 2 diabetes combined with grade 1 hypertension (DH1 group), 51 cases of type 2 diabetes and grade 2 hypertension (DH2 group), and 54 cases of type 2 diabetes and grade 3 hypertension (DH3 group).Meanwhile, 40 people without diabetes and hypertension were enrolled as the control group.The serum Giα-2 and NGAL levels in each group were detected by ELISA.The influence factors of Giα-2 and NGAL were analyzed by multiple linear regression analysis.Results The level of Giα-2 in the DS group was lower than that in the control group, at the same time, the levels of Giα-2 in the DH1 and DH2 and DH3 groups were higher than that of the DS group, and the DH3 group was the highest (all P<0.05).The level of NGAL in the DS group was higher than that of the control group, with the increase of hypertension grades, NGAL increased in the DH1 and DH2 and DH3 groups (all P<0.05).The results of the multivariate linear regression analysis showed that Giα-2 was positively correlated with systolic blood pressure (SBP) (r=0.54, P<0.05), and NGAL was positively correlated with SBP and fasting blood-glucose (FBG) (r=0.55 and 0.14, both P<0.05).Further multiple linear regression analysis showed that SBP was an independent influence factor for Giα-2 level, meantime, SBP and FBG were independent influence factors for NGAL level.Conclusion Serum levels of Giα-2 and NGAL increase in patients with type 2 diabetes and hypertension, and the changes in levels of Giα-2 and NGAL have a certain influence on the occurrence of type 2 diabetes and hypertension.
Keywords：type 2 diabetes mellitushypertensioninhibitory G-protein subunit Gi α-2neutrophil gelatinase-associated lipocalin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )