Comparison of changes in serum inflammatory cytokines and lipid levels after oral administration of rosuvastatin and simvastatin in patients with end-stage renal disease receiving high-throughput maintenance hemodialysis
XU Fang
NIE Daqing
CHEN Wenli
Abstract：Objective To compare the changes in serum inflammatory cytokines and lipid levels after oral administration of rosuvastatin and simvastatin in patients with end-stage renal disease receiving high-throughput maintenance hemodialysis.Methods Seventy-eight patients with end-stage renal disease were randomly divided into the rosuvastatin group and simvastatin group.Patients in the two groups received high-throughput maintenance hemodialysis, followed by oral administration of rosuvastatin in the rosuvastatin group and simvastatin in the simvastatin group.We compared the levels of serum inflammatory cytokines [high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6)] and lipids [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)].Results Compared with the simvastatin group, the levels of hs-CRP, IL-6, and TNF-α decreased after treatment in the rosuvastatin group (all P<0.05).The levels of hs-CRP, IL-6, and TNF-α significantly decreased after treatment in these two groups as compared with those before treatment (all P<0.05).Compared with the simvastatin group, LDL-C decreased after treatment in the rosuvastatin group (P<0.05).The levels of TC, TG, and LDL-C significantly decreased, while HDL-C increased after treatment in these two groups as compared with those before treatment (all P<0.05).Conclusion Both rosuvastatin and simvastatin can decrease the levels of hs-CRP, TNF-α, IL-6, TC, and TG, and increase the LDL-C level, but the efficacy of rosuvastatin is better than that of simvastatin.
Keywords：rosuvastatinsimvastatinhigh-sensitivity C-reactive proteintumor necrosis factor-αinterleukin-6total cholesteroltriglyceridelow-density lipoprotein cholesterolhigh-density lipoprotein cholesterol
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 25-28 )