Comparision of CDA gene polymorphism between Xinjiang Uygur and Han NSCLC patients
WANG Yanna
FEI Jing
CHENG Yanfang
MENG Lingli
WANG Hui
GONG Ping
Abstract：Objective To analyze the cytidine deaminase (CDA) gene polymorphism in Uygur and Han patients with non-small-cell lung cancer (NSCLC) in Xinjiang Uygur autonomous region.Methods Totally 120 cases of newly diagnosed advanced NSCLC patients, including 53 cases of Uygur (Uygur group) and 67 cases of Han nationality (Han group), were selected to detect the CDA A79C and G208A gene polymorphisms by direct sequencing.Results The frequencies of CDA A79C and G208A genotypes were in accordance with Hardy-Weinberg equilibrium (all P>0.05).The frequencies of A79C AA, AC, CC genotypes and A and C alleles were 75.4%, 18.9%, 5.7%, 84.9%, and 5.1%, respectively in the Uygur group, versus 52.2%, 29.9%, 17.9%, 67.2%, and 32.8% in the Han group (all P<0.05).The frequencies of G208A GG, GA genotypes and G and A alleles were 94.3%, 5.7%, 97.2%, and 2.8%, respectively in the Uygur group, versus 77.6%, 22.4%, 88.8%, and 11.2%, respectively, in the Han group (all P<0.05).Conclusion There are racial differences in the genetic polymorphisms of CDA A79C and G208A between the Uygur and Han nationalities in Xinjiang.
Keywords：cytidinedeaminasecytidinedeaminasegenegenepolymorphismnon-small-celllungcancer
Publication Date：2017-01-01
Pages：4( 1-4 )