Expression and clinical significance of IL-22BP,IL-22,and STAT3 in human gastric cancer tissues
JIANG Maoqin
LAI Mingyu
XIE Fang
JIANG Dan
LU Ting
Abstract：Objective To detect the expression of interleukin-22 (IL-22)binding protein (IL-22BP),IL-22,signal transducer and activator of transcription-3 (STAT3)in the tissues of patients with gastric cancer,and to explore its signifi-cance. Methods Using immunohistochemical SP method to stain 37 cases of gastric cancer tissues and their matched nor-mal gastric tissues which were obtained from the proximal margin of the resection and beyond 5 cm to the gastric cancer sec-tion,the expression of IL-22BP,IL-22,and STAT3 was detected,and the relationships of the three parameters with clini-copathological features of gastric cancer were analyzed. Results The positive expression rates of IL-22BP in the gastric cancer tissues and the normal gastric tissues were 67. 6% (25 / 37)and 18. 9% (7 / 37);the positive expression rates of IL-22 in the gastric cancer tissues and the normal gastric tissues were 73. 0% (27 / 37)and 18. 9% (7 / 37);the positive expression rates of STAT3 in the gastric cancer tissues and the normal gastric tissues were 75. 8% (28 / 37)and 24. 3%(9 / 37),respectively. Significant differences were found in the positive expression rates of the three parameters between the gastric cancer tissues and the normal gastric tissues (all P < 0. 01). The positive expression of IL-22BP,IL-22,and STAT3 in the gastric cancer tissues was significantly related with the clinical stage,depth of invasion,and lymph node me-tastasis of the patients with gastric cancer (all P < 0. 05),but not related with gender and age (all P > 0. 05). In the gas-tric cancer tissues,the expression of IL-22BP was positively correlated with the expression of IL-22,and STAT3 (r =0. 526,0. 383,respectively;all P < 0. 05),and the expression of IL-22 was positively correlated with the expression of STAT3 (r = 0. 342,P < 0. 05). Conclusion IL-22BP,IL-22,and STAT3 are highly expressed in the gastric cancer tis-sues,the expression of them is related with the invasion and metastasis of gastric cancer,and the results suggest that they may synergistically promote the occurrence and development of gastric cancer.
Keywords：gastric carcinomainterleukin-22 binding proteinsignal transducer and activator of transcription-3
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 16-19 )