Relationships of NEK2 gene rs10494938 and rs10158205 polymorphisms with genetic susceptibility to hepatocellular carcinoma
WEI Feifei
LIAO Yan
ZHAO Ruiqiang
WANG Hongxue
XIE Yu'an
Abstract：Objective To investigate the correlations between NIMA-related kinase 2 (NEK2) rs10494938 and rs10158205 polymorphisms and the family clustering genetic susceptibility to hepatocellular carcinoma (HCC).Methods We selected 20 HCC families including 20 cases of HCC patients and 59 cases of their immediate family members.In addition, 10 normal families (healthy population) were selected as the control group (40 cases).Each family was in accordance with the Hardy-Weinberg genetic balance and was representative.The genotype distribution frequency of NEK2 rs10494938 and rs10158205 was detected by mass spectroscope.The difference in the allele and genotype distribution was analyzed by unconditional logistic regression analysis.Results There were CC and CG genotypes in rs10494938 locus, including 114 cases of CC genotype and 5 cases of CG genotype.There were CC, CT and TT genotypes in rs10158205 locus, including 69 cases of CC genotype, 45 cases of CT genotype, and 5 cases of TT genotype.There were no significant differences in the frequencies of CC, CG genotypes and alleles G and C in the rs10494938 locus of NEK2 gene between the patients of HCC family, patients of non-HCC family and the normal control family (all P>0.05).There were no significant differences in the frequencies of CC, CT, TT genotypes and alleles T and C of rs10158205 locus (all P>0.05).Conclusion NEK2 rs10494938 and rs10158205 polymorphisms have no correlation with the family clustering genetic susceptibility to HCC in Fusui county of Guangxi.
Keywords：hepatocellular carcinomaserine/threonine kinase NIMA-related kinase 2 genesingle nucleotide polymorphismfamily clusteringgenetic susceptibilityFusui county of Guangxi
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )