Relationship of promoter polymorphisms of Toll-like receptor 4 with risk of acute myocardial infarction
SUN Dandan
WU Yupeng
YANG Jun
LIU Wen
YAN Hong
WANG Honghu
Abstract：Objective To investigate the association between the promoter polymorphisms of Toll-like receptor 4(TLR4)and the risk of acute myocardial infarction(AMI)in Northern Chinese Han population.Methods Two hundred and forty-four patients with AMI(AMI group)and 284 patients without AMI(control group)were enrolled in this study.Polymerase chain reaction restriction fragment length polymorphism was performed to detect the promoter polymorphisms of TLR4(rs10116253 and rs10983755).The distributions of genotypes were evaluated by Chi-square(X2)test.The association between each SNP and CAD risk was determined using multiple logistic regression analysis.Results The distributions of TLR4 rs10116253 and rs10983755 were in Hardy-Weinberg equilibrium.The TLR4 rs10116253 and rs10983755 polymorphisms were not associated with the total risk of AMI(all P>0.05).Compared with those carriers with wild TT genotype,male carriers with variant TC genotype had a 50％lower AMI risk.Compared with the male carriers with wild TT genotype,male carriers with variant genotype(TC+CC)had lower AMI risk by 0.51 fold.Compared with the hyperlipidemic patients with the wild TT genotype,the patients with the TC variant genotype had lower AMI risk by 0.42 fold.In comparison with the hyperlipidemic patients with wild TT genotype,the patients with variant genotype(TC+CC)had lower AMI risk by 0.46 fold.Significant difference was found between them(all P<0.05).However,TLR4 rs10983755 polymorphism showed no statistical significance in the stratification analysis including sex,age,with or without hypertension,with or without diabetes mellitus and with or without dyslipidemia(all P>0.05).Conclusion Our results reveal an association between the promoter polymorphism rs10116253 of TLR4 and AMI risk.The variant genotype of TLR4 rs10116253 can reduce the risk of AMI in male subjects or subjects with hyperlipidemia.
Keywords：acute myocardial infarctionToll-like receptor 4gene polymorphisms
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 17-20 )