Serum level of sTWEAK and its relationship with left ventricule remodeling in patients with dilated cardiomyopathy
ZHANG Jie
HE Fei
GUO Rong
ZHAO Jing
LIANG Ying
WANG Jiajia
LI Xiaohong
WU Xiaodan
Abstract：Objective To investigate the changes of serum soluble tumor necrosis factor-like weak inducer of apoptosis(sTWEAK)in patients with dilated cardiomyopathy(DCM)and its relationship with plasma N-terminal pro-natriuretic peptide(NT-proBNP)and left ventricular mass index(LVMI).Methods One hundred DCM patients(DCM group)and 60 patients without heart failure(control group)were enrolled.The levels of serum sTWEAK and NT-proBNP were determined by ELISA,and LVMI was measured by echocardiography.Results The level of serum sTWEAK in the DCM group was significantly lower than that in the control group,but the levels of NT-proBNP and LVMI were significantly higher than those in the control group(all P<0.05).The level of serum sTWEAK in the DCM group was not correlated with NYHA classification,but it was negatively correlated with NT-proBNP and LVMI(r=-0.524,r=-0.337,all P<0.05),and this correlation still existed after adjusting gender,age,body mass index,total cholesterol,low-density lipoprotein,heart rate,NYHA classification and so on.Multiple stepwise regression analysis showed that serum sTWEAK level was affected by LVMI in DCM patients.Conclusion The level of serum sTWEAK decreases in DCM patients and it could reflect the severity of left ventricular remodeling.
Keywords：dilated cardiomyopathysoluble tumor necrosis factor-like weak inducer of apoptosisN-terminal pro-natriuretic peptideventricular remodeling
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )