Expression of IL-33 in gastric carcinoma and its significance
XIA Bingxiang
LI Fan
WANG Xuan
YUAN Zhenhua
ZHENG Suwen
ZHANG Yewei
Abstract：To investigate the expression of IL-33 in gastric carcinoma tissues and its significance.Methods Cancer tissues and adjacent tissues of 98 patients with gastric cancer were selected, among whom, there were 16 cases with early gastric cancer, 82 cases with advanced gastric cancer, 76 cases with lymph node metastasis and 22 cases without lymph node metastasis.Meanwhile, we selected 36 cases of normal gastric tissues from healthy people as the control group.Immunohistochemical S-P method and real-time PCR were applied to detect the expression of IL-33 and its mRNA in gastric carcinoma tissues as well as in normal gastric tissues.We analyzed the relationship between the expression of IL-33 and clinicopathological features of gastric carcinoma tissues.Survival curves between IL-33 expression positive and negative patients were made using the Kaplan Meier method, and the median survival time was compared.Results The positive rate of IL-33 expression in gastric cancer tissues was higher than that in normal gastric tissues (P<0.05).No significant difference was found in the positive rate of IL-33 expression between in early gastric cancer and lymph node metastasis-negative gastric cancer tissues and in the normal gastric tissues (all P>0.05), while significant difference was found between in advanced gastric cancer and lymph node metastasis-positive gastric cancer tissues and in the normal gastric tissues (all P<0.05).The relative expression of IL-33 mRNA in gastric cancer tissues was higher than that in the normal gastric tissues (P<0.05).After the comparison of those between gastric cancer tissues with and without lymph node metastasis, significant difference was found (P<0.05).The expression of IL-33 was not related with gender, age, tumor growth and tumor size (all P>0.05), but it was correlated with tumor differentiation, tissue infiltration, lymph node metastasis, distant metastasis and clinical stage (all P<0.05).The median survival time was 30.6 months in IL-33 negative patients and 22.7 months in patients with positive IL-33 expression, P=0.001.Conclusion The increment on the level of IL-33 in gastric cancer tissues indicates that IL-33 may be involved in the occurrence and development of gastric cancer and predict poor prognosis.
Keywords：stomach neoplasmsinterleukin-33lymph node metastasisprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )