Effects of different doses of curcumin on the recovery of tissue and hind limb function after spinal cord injury in rats
HAO Qin
LIU Jian
WANG Huiwei
YANG Yanling
SHEN Juan
ZHAO Lin
JI Zhe
Abstract：Objective To observe the effects of different doses of curcumin on motor function and tissue structure of rats after spinal cord injury (SCI).Methods Sixty female SD rats were divided into five groups in random, high-dose curcumin group, medium-dose curcumin group, low-dose curcumin group, SCI group and sham group (Group).We used HI-0400 impactor (produced by American PSI Company) to create the animal models of acute hitting SCI in the above groups except the sham group.Rats in the high-dose, medium-dose, and low-dose curcumin groups were administered 200, 100 and 50 mg/kg curcumin after SCI by gavage.Rats in the SCI and sham groups were given the same amount of normal saline at the same time.After 1, 3 and 7 d, the spinal cord tissues of rats in each group were taken for HE staining.Then, we used the neural function of BBB scale (motor function scale) and Rivlin oblique plate experiment to evaluate rats' motor function at 4, 7, 14, 21 and 28 d after operation.Results In the high-dose, medium-dose and low-dose curcumin groups, the morphology of the spinal cord in rats improved better than that of the SCI group, and degeneration and necrosis of neurons in spinal cord was lighter.The medium-dose curcumin group was the most obvious.In the BBB score and Rivlin oblique plate experiment, the maximum inclined plate angle was significantly lower than that of the sham group after SCI (P<0.05).Conclusions Curcumin can promote the recovery of spinal cord tissue structure and motor function after SCI in rats, and 100 g/kg curcumin is the best in the range of 50 to 200 g/kg.
Keywords：spinal cord injurycurcuminspinal cordhistomorphologyhind limb motor functionanimal experiments
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 11-14 )