Subthalamic nuclei targeting in deep brain stimulation surgeries in patients with Parkinson's disease and dystonia
ZHANG Hua
SHI Lin
YANG Anchao
ZHU Guanyu
CHEN Yingchuan
ZHANG Jianguo
Abstract：Objective To explore the feasibility of subthalamic nuclei (STN) targeting by magnetic resonance imaging (MRI) and intraoperative microelectrode recording before deep brain stimulation (DBS) in patients with Parkinson's disease and dystonia.Methods We selected 202 patients (382 sides) undergoing STN-DBS for Parkinson's and dystonia.STN sites targeted by MRI were testified by intraoperative microelectrode recording after opening cranium before DBS.Results ① STN targeted by MRI were clearly manifested in 288 of 382 sides, were ordinarily manifested in 72 sides and blurred in 22 sides.② The STN signals harvested in all 382 sides.The number of trajectories required to obtain sufficient STN activity was one in 339 sides, two in 43 sides.The STN signals were typical in 356 in 382 sides (93.1%) and untypical in 26 sides (6.9%).The mean STN length was (5.9±1.1) mm.③ 341 sides (94.7%) received typical STN signals in 360 satisfactory STN-targeting sides (clearly and ordinarily), as 15 sides (68.2%) received typical STN signals in 22 unsatisfactory STN-targeting sides before DBS.Conclusion MRI and intraoperative microelectrode recording can target subthalamic nuclei (STN) accurately before DBS in patients with Parkinson's disease and dystonia.
Keywords：deep brain stimulationsubthalamic nucleiParkinson's diseasedystoniamagnetic resonance imagingmicroelectrode recording
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 7-10 )