Expression of RAGE, MKK7 and JNK1 in patients with type 2 diabetes mellitus complicated with hepatocellular carcinoma
MENG Liheng
HUANG Yao
XU Mengjie
ZHOU Jia
LI Li
QIN Yingfen
Abstract：Objective To investigate the expression and significance of receptor for advanced glycation end products (RAGE),mitogen-activated protein kinase kinase 7 (MKK7) and c-Jun N-terminal protein kinase 1 (JNK1) in patients with type 2 diabetes mellitus complicated with hepatocellular carcinoma.Methods The resected cancer tissues and corresponding normal tissues were obtained from 18 patients with type 2 diabetes mellitus complicated with hepatocellular carcinoma (DMHC group) and 30 patients with simple hepatocellular carcinoma (HCC group).The expression of RAGE,MKK7 and JNK1 was detected by Western blotting.The relationships of RAGE,MKK7 and JNK1 expression in the two groups with the clinical and pathological parameters of the patients were analyzed as well as the relationship among RAGE,MKK7 and JNK1.Results The expression levels of RAGE,MKK7 and JNK1 were higher in the cancer tissues of both DMHC and HCC groups than those in their corresponding adjacent normal tissues (all P ＜ 0.05).Compared with the HCC group,MKK7 and JNK1 expression in the cancer tissues of the DMHC group was higher (all P ＜ 0.05).In the HCC group,the relative expression levels of RAGE,MKK7 and JNK1 in patients with poor differentiation were higher than those in patients with high differentiation,and in the DMHC group,the relative expression levels of MKK7 and JNK1 in patients with poor differentiation were higher than those in patients with high differentiation (all P ＜ 0.05).There was a positive correlation between the expression of RAGE,MKK7 and JNK1 in the DMHC group and HCC group (all P ＜ 0.05).Conclusions The increase of RAGE expression may be involved in the occurrence and development of hepatocellular carcinoma.The expression of MKK7 and JNK1 might promote the progress of hepatocellular carcinoma in hyperglycemic state.MKK7 and JNK1 may be regulated by RAGE to some extent.
Keywords：hepatocellular carcinomadiabetes mellitustype 2receptor for advanced glycation end productsmitogen-activated protein kinase kinase 7c-Jun N-terminal protein kinase 1
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )