Relationship between ACE gene polymorphism and idiopathic dilated cardiomyopathy in patients of south China
CHEN Wen
ZHAO Tie
CHEN Daidi
LIU Yili
XIONG Meng
GUI Qingjun
Abstract：Objective To explore the relationship between angiotensin-converting enzyme ( ACE ) rs4646994 gene polymorphism and idiopathic dilated cardiomyopathy ( IDC) in patients of south China .Methods We collected 64 IDC pa-tients in south China as the IDC group and 120 healthy persons as the control group , then investigated the ACE rs4646994 genotype in the fasting peripheral venous blood collected from the two groups by RT -PCR and detected the ACE concentra-tion in the plasma by UV spectrophotometer .Results In the IDC group, the frequency of DD genotype was 28.13%, which was significantly higher than that of the control group (10.00%) and the frequency of D allele was 50.79%, which was significantly higher than that of the control group (33.75%) (all P<0.05), but there was no significant difference in ID genotype, II genotype and I allele (all P>0.05).In the IDC group and control group , the ACE concentration in pa-tients with DD genotype was significantly higher than that of patients with ID genotype and II genotype ( P<0.05 or P<0.01), but no significant difference was found in the ACE concentration among the people with the same genotypes (all P>0.05).Conclusion The insertion/deletion polymorphism of ACE gene is associated with IDC , and the DD genotype and D allele of ACE gene may probably increase south China Han population at risk of IDC .
Keywords：angiotensin-converting enzymeidiopathic dilated cardiomyopathygene polymorphismsouth ChinaHan nationality
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 24-26 )