Effects of aerobic and resistant exercise on changes of serum glucagon-like peptide-1 and blood glucose in prediabetic patients
LUO Zuchun
DAI Xia
ZHANG Taihui
MA Xiaojun
CHEN Lulu
LUO Haibin
Abstract：Objective To oserve the effects of aerobic and resistant exercise on glucagon-like peptide-1 (GLP-1 ) and blood glucose in prediabetic patients.Methods A total of 105 prediabetic subjects were randomly divided into group A (n =34),group B (n =35),and group C (n =36).Patients in the group A received moderate-intensity aerobic exer-cise,in group B received resistant exercise,and there was no intervention in patients of group C.Before intervention and at 3,6,12 and 18 months of intervention,fasting blood glucose (FPG),serum GLP-1,and 2-hour postprandial glucose (2 h PG)were detected in the three groups;the change rate of serum GLP-1 and the rate of blood glucose were calculated after 18-month intervention.Results Compared with the baseline,GLP-1 was increased in the group A at 12 and 18 months of intervention,which was decreased at 6 months and was increased at 18 months in the group B,and that was decreased in group C at 6,12 and 18 months (all P <0.05).Compared with group C,GLP-1 was increased in the groups A and B at 12 and 18 months of intervention (all P <0.05).Compared with group B,GLP-1 was increased in the group A at 6 and 12 months of intervention (all P <0.05).Compared with the baseline,FPG was decreased in the group A at 3,6,12 and 18 months of intervention,which was decreased in the group B at 3 and 18 months of intervention,and that was increased in the group C at 18 months (all P <0.05).Compared with group C,FPG was decreased in the groups A and B at 3,6,12 and 18 months (all P <0.05).Compared with the baseline,2 h PG was increased in the group C at 3 months of interven-tion (P <0.05).Compared with group C,2 h PG was decreased in the groups A and B at each time point (all P <0.05), except for that of group B at 12 months.At 18 months of intervention,the change rate of FPG or 2 h PG was negatively cor-related with the change rate of GLP-1 (r =-0.537 or -0.314,all P <0.05).Conclusion Both the aerobic and resist-ant exercise intervention can retard the declining of GLP-1 and increase the blood glucose in prediabetic patients,but the effect of aerobic exercise is better than that of resistant exercise on improvement of GLP-1.
Keywords：diabetes mellitusimpaired glucose regulationglucagon-like peptide-1aerobic exerciseresistant exer-cise
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 18-21 )